Yehlisiwe i-L-Glutathione (GSH) CAS 70-18-8

Yini Eyehlisiwe i-L-Glutathione?

I-L-glutathione eyehlisiwe, evame ukufushaniswa njenge-GSH, i-tripeptide eyenzeka ngokwemvelo eyakhiwe i-L-glutamic acid, i-L-cysteine ​​​​ne-glycine. Igama layo lamakhemikhali yi-γ-L-glutamyl-L-cysteineylglycine.

I-glutathione eyehlisiwe ngokwezentengiselwano ivamise ukunikezwa njengempushana ecwebezelayo emhlophe noma ecishe ibe mhlophe. Inombolo yayo ye-CAS ngu-70-18-8, ifomula ye-molecular ithi C₁₀H₁₇N₃O₆S, futhi isisindo se-molecular ngu-307.32 g/mol.

Izinsalela ze-cysteine ​​​​ziqukethe iqembu le-sulfhydryl elisebenzayo elibhekene nezakhiwo zokunciphisa ze-GSH. Ukuchayeka kumoya-mpilo, izinga lokushisa eliphakeme, i-pH engafanele noma izinsimbi zokulandelela kungaguqula i-glutathione encishisiwe ibe i-glutathione ene-oxidized, eyaziwa nangokuthi i-GSSG.

Igama elithi 'glutathione' akufanele lisetshenziswe ngaphandle kokukhomba ukuthi into enikeziwe yehlisiwe yini i-GSH noma i-GSSG eyenziwe nge-oxidized.

Amaqiniso asheshayo e-L-Glutathione ancishisiwe

Ibanga eliqondile, umzila wokukhiqiza, ukucaciswa nokufaneleka kokulawula kufanele kuqinisekiswe kwikhotheshini ye-AOZUN kanye nemibhalo yeqoqo.

I-Glutathione Encishisiwe vs I-Oxidized Glutathione

I-glutathione eyehlisiwe ne-oxidized ihlobene kodwa izinto ezahlukene.

Umphumela ophezulu we-glutathione ophezulu awukhombisi okuqukethwe okuphezulu kwe-GSH encishisiwe. Abathengi kufanele bacele indlela ekwazi ukuhlukanisa i-GSH ne-GSSG.

Kungani Umehluko we-GSH-to-GSSG Ubalulekile?

I-glutathione encishisiwe ingakwazi ukwenza i-oxidize ngesikhathi sokukhiqiza, ukomisa, ukugcinwa, ukulungiswa kwesisombululo kanye nokwakhiwa.

Uma indlela yokuhlaziya ingahlukanisi i-GSH ne-GSSG, umphumela ungase ungachazi ngokunembile inani le-glutathione encishisiwe emkhiqizweni.

Kuzinhlelo zokusebenza ezizwelayo kwikhwalithi, imininingwane kufanele ikhulume ngokuhlukile:

• Ukuhlolwa kwe-glutathione okuncishisiwe

• I-GSSG

• Izinhlanganisela ezihambisanayo ngazinye

• Ukungcola okuphelele kwezinto eziphilayo

• Amanzi noma ukulahlekelwa lapho omiswa

• Ukucaca kwesixazululo nombala

Kufanele Iqinisekiswe Kanjani Ikhwalithi Ye-Glutathione?

Ikhwalithi ye-glutathione eyehlisiwe kufanele ihlolwe kusetshenziswa ukuhlolwa kobunikazi, ukuhlolwa komthamo okuqinisekisiwe nokuhlaziywa okuqondile kokungcola. I-HPLC noma enye indlela efanelekile yokuhlukanisa ingahlukanisa ifomu elincishisiwe elifiswayo ku-glutathione ene-oxidized kanye nezinhlanganisela ezihambisanayo ngempumelelo kakhulu kunokuhlola okuphelele okungaqondile.

Kungani i-HPLC kanye ne-GSSG Testing Matter

Ukuhlola ukubonakala kuphela kanye nokuhlolwa okuphelele kungase kuphuthelwe yi-oxidation noma ukungcola okuhlobene eduze.

Indlela efanele ye-chromatographic ingasekela ukuhlolwa:

• Okuqukethwe kwe-glutathione okwehlisiwe

• I-glutathione ene-oxidized

• Izinto ezihlobene ngazinye

• Ukungcola okuphelele kwezinto eziphilayo

• Ukuvumelana kweqoqo-kuya-inqwaba

• Izinguquko zokuzinza

Indlela yokuhlaziya nezinga lereferensi kufanele kushiwo ekucacisweni noma ekuhloleni inqubo.

I-AOZUN Eyehlisiwe Izicaciso ze-Glutathione

Ukuze uthole ukudla, umsoco, izimonyo noma iziqu zemithi, abathengi bangaphinda badinge i-GSSG, izinhlanganisela ezihlobene, ukungcola okuyisisekelo kanye nemikhawulo ye-microbiological.

Imibandela yokugcina yokwamukela kufanele iqinisekiswe kusetshenziswa ukucaciswa kwe-AOZUN yamanje kanye neqoqo le-COA.

Ukuhlola Ikhwalithi Engeziwe Okunconyiwe

Ngokuya ngesicelo, izivivinyo ezilandelayo zingacelwa:

Imikhawulo yereferensi ayiyona ingxenye ngokuzenzakalela yokucaciswa okujwayelekile kwe-AOZUN. Kufanele kuvunyelwane ngazo ngaphambi kokuqinisekiswa kwe-oda.

Isho Ukuthini Ukucaciswa Okuyinhloko?

Isivivinyo

Ukuhlolwa kubonisa okuqukethwe kwe-glutathione okulinganiselwe. Umphumela kufanele usho ukuthi ibalwa ngendlela eyiyo noma yomisiwe.

Inani elibikiwe elingaphezu kuka-100% lingenzeka ngenxa yokungaqiniseki kokuhlaziya nokubalwa kwesisekelo esomisiwe. Akusho ukuthi isampula ngokomzimba iqukethe izinto ezingaphezu kuka-100%.

I-Specific Optical Rotation

I-Glutathione iqukethe izinsalela ze-chiral amino-acid. Ukuzungezisa okuqondile kwe-optical kusiza ukuqinisekisa ubunikazi be-stereochemical futhi kungaveza umehluko omkhulu ekwakhiweni.

Indlela yokugxilisa ingqondo, i-solvent, izinga lokushisa kanye nendlela yokubona esetshenziswe ekuhlolweni kufanele kushiwo.

I-GSSG

I-GSSG iwuhlobo lwe-oxidized ye-glutathione. I-GSSG ephakeme ingase ibonise i-oxidation phakathi nokucubungula noma ukugcinwa.

Umkhawulo ozinikele we-GSSG ufundisa kakhulu kunokuncika kuphela ekuhlolweni okuphelele.

Ukulahlekelwa Ekumisweni

Ukulahlekelwa ekomisweni kulinganisela umswakama nezinye izinto eziguquguqukayo. Umswakama owedlulele ungathinta ukuhlolwa, ukuzinza, ukugeleza kanye nezinga le-oxidation.

I-Chloride ne-sulfate

Lawa ma-ion angavela ezintweni ezingavuthiwe, ukuvutshelwa, ukuhlanzwa noma ukulungiswa kwe-pH. Imikhawulo isiza ukusungula ukuvumelana kokuhlanza.

I-ammonium

I-ammonium eyinsalela ingahlotshaniswa nemisoco yokuvutshelwa noma ukucutshungulwa komfula. Ukudla okuzwelayo, izimonyo kanye nezicelo zemithi zingadinga umkhawulo olawulwayo.

Insimbi

I-Trace iron nezinye izinsimbi zoguquko zingase zenze i-oxidation. Ngakho-ke izinga lensimbi eliphansi lingasekela kokubili ubumsulwa nokuzinza.

I-Sulfated Ash

Umlotha ofakwe amanzi ulinganisela izinsalela ze-inorganic ezingaguquki. Umphumela ophezulu ungase ubonise usawoti noma okunye ukungcola okungaphili.

Ukungcola Okuyisisekelo

Uhlolo olujwayelekile 'lwe-heavy metal njenge-Pb' lungase lunganele kulo lonke uhlelo lokusebenza olulawulwayo. Iziqu zesimanje zingadinga imiphumela yomuntu ngamunye yokuhola, i-arsenic, i-cadmium ne-mercury.

Ikhwalithi ye-Microbiological

Izinto ezihloselwe ukudla, umsoco noma izimonyo zingadinga imikhawulo ecacisiwe yama-microbial.

Ukuhlolwa kwamakhemikhali okuphezulu akubonisi ikhwalithi eyamukelekayo ye-microbiological.

Ikhiqizwa Kanjani I-Glutathione Encishisiwe?

I-glutathione eyehlisiwe ngokwezentengiselwano ivamise ukukhiqizwa ngokuvutshelwa kwe-microbial okulawulwayo okulandelwa ukuhlukaniswa, ukuhlanzwa, ukugxilisa ingqondo, ukucwebezela kanye nokomisa.

Ukulandelana kokukhiqiza okujwayelekile kungabandakanya:

1. Ukulungiswa kwendawo yokuvutshelwa

2. Ukuvutshelwa kwe-microbial okulawulwayo

3. Ukuhlukaniswa kweseli noma ukukhishwa

4. Ukuhlanzwa

5. Ukugxila

6. I-Crystallization

7. Ukomisa

8. Ukugaya noma ukusefa

9. Ukuhlolwa kwekhwalithi

10. Ukupakishwa kokuvikela umswakama nomoya-mpilo

Imvelo yangempela yokukhiqiza, i-fermentation substrate kanye nezinsiza zokucubungula kufanele ziqinisekiswe nomphakeli.

I-Fermentation-Derived vs Synthetic Glutathione

Ukuvutshelwa kusetshenziselwa kakhulu ukuthengisa kwe-glutathione encishisiwe ngoba inganikeza ifomu elidingekayo le-stereochemical futhi isekele ukukhiqizwa kwesikali sezimboni.

Abathengi kusafanele baqinisekise:

• Ubunikazi be-Microorganism

• Isimo se-GMO noma okungesona se-GMO

• I-substrate yokuvutshelwa

• Isimo semvelaphi yezilwane

• Izingozi ze-Allergen

• Izinsiza zokucubungula

• Izincibilikisi ezisele

• Izilawuli zokuhlanza

• Ukulandeleka kweqoqo

'I-Fermentation-derived' ayisunguli ngokuzenzakalelayo ukuthobela ukudla, ikhemisi, imifino, i-vegan, okungeyona i-GMO, i-halal noma i-kosher.

Ayatholakala Amabanga E-Glutathione Ancishisiwe

Ibanga Lokudla Okunomsoco noma Lokuhlanganisa Ukudla

Izinto ezihloselwe izithasiselo noma imikhiqizo yokudla zingadinga:

• Izilawuli ezifanele zokukhiqiza ukudla

• Imikhawulo ye-Microbiological

• Imikhawulo yokungcola kwe-elemental

• Isitatimende se-Allergen

• Isitatimende se-GMO

• Izilawuli zokuncibilika kwensalela

• Ukuhambisana nemithetho yezwe okuyiwa kulo

Imvume yokusebenzisa i-glutathione ekudleni noma ezithakweni ziyahlukahluka kuye ngamazwe.

Ibanga Lokuzimonyo

I-GSH yezinga lezimonyo kufanele ibe nombala olawulwayo, iphunga, ubumsulwa, i-GSSG, izinsimbi kanye nekhwalithi ye-microbiological.

Umkhiqizi wezimonyo oqediwe uhlala enesibopho sokuphepha kokwakhiwa, ukuzinza, izimangalo kanye nesaziso sokulawula.

IBanga Lezemithi

Izicelo zemithi zingadinga:

• Ukuhambisana ne-pharmacopeial monograph esebenzayo

• Ukukhiqizwa kwe-GMP

• Izindlela zokuhlaziya eziqinisekisiwe

• Iphrofayili yokungcola

• Ukuhlolwa kokungcola kwe-elemental

• Idatha yokuzinza

• Shintsha ukulawula

• Ukwesekwa ngokokulawula

Ukuhlolwa okungama-98% noma u-99% kukodwa akubonisi izinga lezemithi.

IBanga le-Reagent ne-Biochemical

Izicelo zaselabhorethri zingabeka kuqala:

• Ubunikazi

• Isivivinyo

• I-GSSG

• Ukufaneleka kokuhlolwa kwe-enzyme

• Ukucaca kwesixazululo

• Landelela izinsimbi

• Ukusebenza kokuhlaziya okungaguquki

Ibanga le-reagent alifanelekele ngokuzenzakalelayo ukudla, izimonyo noma ukusetshenziswa komtholampilo.

Ibanga le-Oenological

I-Glutathione ingasetshenziswa ezinhlelweni ezithile zokukhiqiza iwayini lapho kuvunyelwe khona. Izinto ze-oenological zingadinga okuqukethwe kwe-GSH okuchaziwe, umswakama, ukungcola okuyisisekelo, ukulebula nolwazi lomthombo wokukhiqiza.

Ukusetshenziswa kufanele kuhambisane nezinga elisebenzayo le-OIV kanye nemithethonqubo yewayini yendawo.

Izicelo Ezincishisiwe ze-Glutathione

Ukwakhiwa Kwezokudla Okunomsoco

I-glutathione encishisiwe efanelekayo ingase isetshenziswe njengesithako kuma-capsules, amaphilisi, izimpushana, iziphuzo noma amanye amafomethi wokungezelela lapho kuvunyelwe ngokomthetho.

Abakhiqizi kufanele bahlole:

• Isimo sesithako esivunyelwe

• Izinga eliphezulu noma elinconyiwe lokusebenzisa

• Ukuzinza komkhiqizo

• Ukuxhumana namaminerali kanye nezithako ze-oxidizing

• Ukunambitha kanye nephunga

• Ukuhlolwa komkhiqizo oqediwe

• Izimangalo zelebula ezivunyelwe

Leli khasi lezinto ezingavuthiwe alinikezi umthamo noma iseluleko sezokwelapha.

Ukudla kanye Neziphuzo Formulations

I-Glutathione ingasetshenziswa ekudleni okuthile, ekuphuzweni nasezinhlelweni ze-oenological, kuncike emithethweni yendawo.

Uhlamvu lwayo olunciphisayo lungase luthinte i-oxidation, umbala nokuzinza kwe-flavour, kodwa umphumela uncike ekubunjweni okuphelele nezimo zokucubungula.

Izinto ezijwayelekile zezimboni noma ze-reagent-grade akufanele zisetshenziswe ekudleni.

Izimonyo Formulations

I-glutathione encishisiwe ingase ifakwe ekwakhiweni kwezimonyo okufanelekayo njengesithako se-antioxidant noma se-skin-conditioning lapho kuvunyelwe ngokomthetho.

Abakhiqizi kufanele baqinisekise:

• Isimo sokulawula isithako

• Ukugxila

• pH

• Ukuzinza kwe-oxidation

• Ukuthuthukiswa kombala

• Iphunga

• Ukuhambisana kokulondoloza

• Ukupakisha

• Ukuphepha komkhiqizo oqediwe

• Izimangalo ezivunyelwe zezimonyo

Umphakeli wezinto ezingavuthiwe akufanele aqinisekise ukushiswa kwesikhumba, ukususwa kombala, ukunciphisa imibimbi noma isikhathi esithile semiphumela ebonakalayo.

Ukukhiqiza Kwemithi

I-glutathione yezinga lemithi efanelekayo ingasetshenziswa njenge-API, i-excipient noma izinto ezicutshungulwayo ezinhlelweni zemithi ezigunyaziwe.

Izinto eziyinqwaba yesithako akumele zimelelwe njengomuthi ojovwayo noma oqediwe. Imikhiqizo eyinyumba idinga ukukhiqizwa okuhlukile, ukuvala inzalo, ukuvala iziqukathi kanye nezilawuli zokulawula.

Izicelo ze-Biochemical and Research

I-glutathione eyehlisiwe isetshenziswa ku:

• Ukuhlolwa kwe-biochemical

• Ucwaningo lwama-enzyme

• Izifundo ze-Redox-system

• Amaprotheni chemistry

• Ukwakhiwa kwebhafa

• Ucwaningo lwamaseli

• Izindinganiso zokuhlaziya

• Izinhlelo zokunciphisa ilabhorethri

Abacwaningi kufanele bakhethe ibanga elifanele indlela yokuhlola kanye nobumsulwa obudingekayo.

Ukwakha Nge-Glutathione Eyehlisiwe

I-GSH iqukethe iqembu le-sulfhydryl elisebenzayo futhi lingakhipha isixazululo.

Okuguquguqukayo okubalulekile kokwakhiwa kuhlanganisa:

• pH

• Izinga lokushisa

• I-oxygen encibilikile

• Ukuchayeka okukhanyayo

• Landelela insimbi nethusi

• Umsebenzi wamanzi

• Ezinye izithako ze-oxidizing

• Isikhala sokupakisha

• Isikhathi sokucubungula

• Uhlelo lokulondoloza

Izinto ezingavuthiwe zekhwalithi ephezulu azikwazi ukunxephezela ukwakheka okuqediwe okungazinzile.

Kungani I-Glutathione I-Oxidize?

Ama-molecule amabili e-glutathione ancishisiwe angakha isibopho se-disulfide, akhiqize i-glutathione ene-oxidized.

I-oxidation ingase isheshise lapho i-GSH ivezwa ku-:

• Umoya

• Izinga lokushisa eliphakanyisiwe

• Izimo ze-alkaline

• Ukukhanya

• Landelela izinsimbi

• Ama-oxidizing agents

• Izikhathi ezinde zokubamba isisombululo

• Ukuvulwa kwesitsha okuphindaphindiwe

Ushintsho kungenzeka lungabonakali ngaso sonke isikhathi, ngakho ukuhlolwa kwamakhemikhali kuyadingeka.

Ungakuthuthukisa Kanjani Ukuzinza Kwe-GSH Kumafomula

Kuye ngomkhiqizo ohlosiwe, abakhi bangahlola:

• Ukulawula i-pH efanelekile

• Ukucutshungulwa kwe-oxygen ephansi

• I-nitrogen headpace

• Ama-Chelating agents

• Izinto zokusetshenziswa eziphansi zensimbi

• Ukupakishwa kokuvikela ukukhanya

• Kwehlisiwe izinga lokushisa lokucubungula

• Isikhathi esifushane sokubamba isixazululo

• Ama-antioxidants ahambisanayo

• Umsebenzi wamanzi ofanelekile

• Izifundo zokuzinza komkhiqizo oqediwe

Noma yiluphi uhlelo lokuzinzisa kufanele luhambisane nemithetho esebenzayo yokudla, yezimonyo noma yezemithi.

Ukulungiswa Kwesixazululo Se-Glutathione Encishisiwe

Okokusetshenziswa kokuhlaziya noma ukukhiqiza:

1. Sebenzisa amanzi asezingeni elifanele.

2. Sebenzisa okokusebenza okuhlanzekile, okunensimbi encane.

3. Lungiselela kuphela inani elidingekayo.

4. Nciphisa ukuchayeka emoyeni.

5. Gwema ukushisisa okungadingekile.

6. Lawula i-pH.

7. Vikela isixazululo ekukhanyeni lapho kufanele khona.

8. Sebenzisa isisombululo ngokushesha ngaphandle kokuthi ukugcinwa kokusekelwa kwedatha okuzinzile kuqinisekisiwe.

9. Qaphela i-GSH ne-GSSG phakathi nezifundo zokuzinza.

Izixazululo ze-GSH ezinamanzi ngokuvamile zi-oxidize kalula kunempushana eyomile evaliwe.

Ukucabangela Ukuhambisana

Ngaphambi kokwakhiwa kwezentengiso, hlola ukuhambisana ne:

• Ithusi ne-iron nosawoti

• Ama-Peroxides

• Ama-oxidizer aqinile

• Izithako ze-alkaline

• Amaminerali premixes

• Izitshalo ze-botanical

• Amasistimu we-flavour

• Izilondolozi

• Ama-surfactants

• Izinto zokupakisha

Izithako eziqukethe insimbi zingase zibe nomthelela omkhulu ekufakweni kwe-oxidation.

Indlela Yokuhlola Umhlinzeki We-Glutathione Owehlisiwe

Umhlinzeki oqeqeshiwe kufanele akwazi ukuqinisekisa:

1. Ifomu elincishisiwe, i-GSH

2. Inombolo ye-CAS

3. Indlela yokukhiqiza

4. Indlela yokuhlola kanye nesisekelo sokubala

5. Umkhawulo we-GSSG

6. Imikhawulo yento ehlobene

7. Ukujikeleza kwe-Optical

8. Umswakama noma ukulahlekelwa lapho omiswa

9. Ukungcola okuyisisekelo

10. Imikhawulo ye-Microbiological

11. I-fermentation organism

12. I-GMO kanye nesimo se-allergen

13. Isimo semvelaphi yezilwane

14. Ukupakisha

15. Isitoreji nempilo yeshelufu

16. Ukutholakala kwe-COA, TDS kanye ne-SDS

17. Inqubo yokulawula ushintsho

18. Ukufaneleka kokulawula kwemakethe ehlosiwe

Umphakeli akufanele athembele kuphela kumphumela wokuhlanzeka lapho enikeza izinto zokusebenza ezilawulwayo.

Ukuhlolwa Kwekhwalithi Okungenayo Okunconyiwe

Kuye ngebanga, abathengi bangaqinisekisa:

• Ubuqotho bokupakisha

• Ilebula nenombolo yeqoqo

• Ukubukeka

• Ukucaca kwesixazululo

• Ukuhlonza

• Isivivinyo

• Ukujikeleza kwe-optical okuqondile

• I-GSSG

• Izinhlanganisela ezihlobene

• Ukulahlekelwa ekomisweni

• Izinsalela ekushiseni

• I-Chloride

• I-sulfate

• I-ammonium

• Insimbi

• Ukungcola okuyisisekelo

• Ikhwalithi ye-Microbiological

• Ukuhambisana ne-COA

Amasampula agciniwe kufanele avikelwe kumswakama, ukushisa, ukukhanya nomoya-mpilo.

Ukupakisha

Iphakethe lemboni elijwayelekile lingasebenzisa:

• Izikhwama zangaphakathi ze-PE ezihambisana nokudla kabili

• Isikhwama sangaphandle esimelana nokukhanya nomswakama

• I-fiber evaliwe noma isigubhu sekhadibhodi

• 25 kg isisindo inetha

• Izikhwama ze-foil ezincane zamasampuli noma ama-oda akhethekile

Usayizi wephakheji wangempela kanye nokokusebenza komugqa kufanele kuqinisekiswe kwikhotheshini.

Ngokusetshenziswa okulawulwayo, izinto zokupakisha zingadinga ukuthintana nokudla, imithi noma amanye amadokhumenti aqondene nohlelo lokusebenza.

Isitoreji kanye Nempilo Yeshelufu

Gcina i-glutathione encishisiwe esitsheni esivalwe ngokuqinile endaweni epholile, eyomile evikelekile:

• Ukukhanya kwelanga okuqondile

• Ukushisa

• Umswakama

• Umoya-mpilo

• Ama-oxidizer aqinile

• Trace-metal ukungcola

• Ukuvulwa kwesitsha okuphindaphindiwe

Amanye amamaki e-reagent agcinwa ku-2–8°C, kuyilapho amanye amamaki enqwaba aqinisekisiwe angase abe nezimo ezinelebula ezihlukile. Landela imiyalelo yesitoreji nempilo yeshelufu eshiwo ngomkhiqizo othengiwe.

Ngemva kokuvula, vala kabusha isikhwama sangaphakathi ngokushesha futhi unciphise ukuchayeka kwe-headspace.

Ukuphepha Nokuphatha

I-glutathione eyehlisiwe imvamisa iphathwa njengento eqinile enengozi ephansi, kodwa inhlanzeko evamile yezimboni isadingeka.

Gwema:

• Ukukhiqiza uthuli oluhamba emoyeni

• Impushana yokuphefumula

• Ukuthintana kwamehlo

• Ukuthinta isikhumba isikhathi eside

• Ukungcoliswa kokudla noma izindawo zokukhiqiza

• Ukuxuba ngezinto ezingabonakali ze-oxidizing

Sebenzisa amagilavu ​​afanelekile, izingubo zamehlo ezivikelayo kanye nokulawula uthuli ngokuya nge-SDS yamanje kanye nokuhlola ubungozi kwendawo yokusebenza.

Ulwazi Lwezokuthutha

I-glutathione eyehlisiwe ivamise ukuhanjiswa njengento engeyona ingozi.

Isimo sokugcina sezokuthutha kufanele siqinisekiswe kusetshenziswa:

• Umhlinzeki wamanje we-SDS

• Ibanga lomkhiqizo

• Usayizi wephakheji

• Indlela yokuthutha

• Izidingo zezwe okuyiwa kulo

Ukuvikelwa kwezinga lokushisa noma umswakama kungase kusabalulekile kwezentengiso ngisho noma umkhiqizo ungekho esigabeni sempahla eyingozi.

Ukucatshangelwa Kokulawula

Isimo sokulawula siyahlukahluka kuye ngezwe kanye nokusebenza.

Ngaphambi kokusebenzisa i-glutathione ekudleni, ekwengezeni, kumkhiqizo wezimonyo noma wokwenza imithi, qinisekisa:

• Isimo sesithako esivunyelwe

• Ibanga elidingekayo

• Imikhawulo yezinga lokusebenzisa

• Izidingo zokulebula

• Izimangalo ezivunyelwe

• Izidingo zokukhiqiza

• Ngenisa ukubhaliswa

• Ukuhlolwa komkhiqizo oqediwe

• Izidingo ze-Pharmacopoeial, uma zikhona

Inombolo ye-CAS noma ukufakwa kuhlu kwe-UNII akusunguli ukugunyazwa kokulawula kokusetshenziswa okuthile.

Imaphi Amadokhumenti Okufanele Umhlinzeki Wempahla Ayinikeze?

Ngokuya ngesicelo, abathengi bangacela:

• Isitifiketi Sokuhlaziya

• Ishidi Ledatha Yezokuphepha

• Ishidi Ledatha Yezobuchwepheshe

• Ukucaciswa komkhiqizo

• Isifinyezo sokugeleza kokukhiqiza

• Isitatimende se-GMP

• Izwe azalelwe kulo

• Isitatimende se-Allergen

• Isitatimende se-GMO

• Isitatimende semvelaphi yezilwane noma isitatimende se-BSE/TSE

• Isitatimende se-Residual-solvent

• Umbiko wokungcola kwe-elemental

• Umbiko we-Microbiological

• Isitatimende sensalela yesibulala-zinambuzane

• Isitifiketi se-halal

• Isitifiketi se-Kosher

• Ukuzinza noma ulwazi lokuhlola kabusha

• Isitatimende sokulawula ushintsho

Cela kuphela noma ukhangise izitifiketi ezisebenza ebangeni elihlinzekiwe kanye nesiza sokukhiqiza.

Kungani Umthombo Wehliswa i-L-Glutathione kusuka ku-AOZUN?

I-AOZUN isekela abathengi bamazwe ngamazwe abafuna i-L-glutathione encishisiwe yezinhlelo zokusebenza ezifanelekayo zokudla okunomsoco, ukudla, izimonyo, amakhemikhali ezinto eziphilayo kanye nezokukhiqiza imithi.

Ukwesekwa kwezentengiso kungase kuhlanganise:

• Ukubuyekezwa kwebanga nezincazelo

• I-COA eqondene neqoqo

• Ingxoxo yemfuneko ye-GSH ne-GSSG

• Izinketho zokupakisha

• Ukuhlolwa kwesampula

• Ukuxhumanisa amadokhumenti

• Thumela usekelo

• Ukuhlolwa komuntu wesithathu

• Ukuhlelwa kokuthunyelwa kwamazwe ngamazwe

• Ukuxhumana kwezobuchwepheshe ngesikhathi sokufaneleka komphakeli

Ibanga lomkhiqizo, ukucaciswa, umthombo wokukhiqiza, isimo sokulawula kanye nokufaneleka kokusetshenziswa okuhlosiwe kufanele kuqinisekiswe kwikhotheshini yokugcina nenkontileka.

Ulwazi Okufanele Ulufake ku-RFQ Yakho

Ukuze uthole ikhotheshini enembile, hlinzeka:

• Igama lomkhiqizo: I-L-Glutathione eyehlisiwe

• Inombolo ye-CAS: 70-18-8

• Isicelo esihlosiwe

• Ibanga elidingekayo

• Imfuneko yokuhlolwa

• Inani eliphakeme kakhulu lama-GSSG

• Imikhawulo yento ehlobene

• Imikhawulo yokungcola kwe-elemental

• Izidingo ze-Microbiological

• Izitifiketi ezidingekayo

• Oda inani

• Imfuneko yokupakisha

• Indawo oya kuyo

• Imfuneko yesampula

• Isheduli yokulethwa

Uma ushintsha umphakeli okhona, namathisela ukucaciswa kwamanje noma i-COA emele.

imibuzo ejwayelekile ukubuzwa

Yini encishisiwe i-L-glutathione?

I-L-glutathione eyehlisiwe i-tripeptide eyakhiwe i-glutamate, i-cysteine ​​​​ne-glycine. Ivamise ukufushaniswa njenge-GSH.

Ithini inombolo ye-CAS ye-glutathione encishisiwe?

Inombolo yayo ye-CAS ngu-70-18-8.

Siyini isisindo samangqamuzana e-glutathione?

I-glutathione eyehlisiwe inesisindo samangqamuzana esingu-307.32 g/mol.

Ingabe i-glutathione iyafana ne-glutathione encishisiwe?

Igama elithi 'glutathione' kwesinye isikhathi lisetshenziswa ngokwejwayelekile. Ukucaciswa kokuthenga kufanele kusho ukuthi umkhiqizo wehlisiwe yini i-glutathione, GSH, noma i-glutathione ene-oxidized, GSSG.

Iyini i-GSSG?

I-GSSG iyi-glutathione ene-oxidized eyakhiwa lapho ama-molecule amabili e-GSH enza isibopho se-disulfide. Kuyinkomba ebalulekile yekhwalithi nokuzinza.

Ingabe i-glutathione encishisiwe iyancibilika emanzini?

Yebo. I-glutathione encishisiwe iyancibilika emanzini futhi kufanele ikhiqize isixazululo esicacile, esingenambala endaweni yokuhlola efanele.

Kungani i-GSSG kufanele ihlolwe ngokwehlukana?

I-assay isiyonke ingase ingahlukanisi i-glutathione encishisiwe nefomu layo le-oxidized. Ukuhlola okuhlukile kwe-GSSG kunikeza ulwazi olungcono mayelana ne-oxidation nokuqukethwe kwe-GSH okusebenzayo.

Ingabe i-98% yebanga lemithi ye-glutathione?

Hhayi ngokuzenzakalelayo. Ibanga lezemithi libuye lincike ekucacisweni kwe-pharmacopoeial, uhlelo lwe-GMP, ukungcola, ukuzinza, imibhalo kanye nokusetshenziswa okuhlosiwe kokulawula.

Ingabe i-glutathione yezinga lokudla ingasetshenziselwa umjovo?

Cha. Ibanga lokudla noma lenqwaba yesithako akufanele lisetshenziswe njengomkhiqizo ojovwayo. Ukusetshenziswa komjovo kudinga umkhiqizo womuthi oyinyumba ogunyaziwe.

Ingabe i-glutathione iqinisekisa ukugqama kwesikhumba?

Cha. Umphakeli wezinto ezingavuthiwe akufanele aqinisekise ukwenziwa mhlophe noma isikhathi esithile semiphumela ebonakalayo. Ukusebenza kwezimonyo kuncike ekwakhiweni, ekugxiliseni, ekuzinzeni, ezimweni zokusetshenziswa nezimangalo ezivunyelwe.

Ingabe i-glutathione vegan?

Ingase ikhiqizwe ngokuvutshelwa, kodwa isimo se-vegan kufanele sisekelwe ulwazi mayelana ne-microorganism, i-fermentation medium, izinsiza zokucubungula kanye nendawo yokukhiqiza.

Ingabe i-glutathione etholakala ngokuvutshelwa ngokuzenzakalelayo ayiyona i-GMO?

Cha. Isimo se-GMO kufanele siqinisekiswe kusetshenziswa imibhalo yabahlinzeki.

Kufanele igcinwe kanjani i-glutathione encishisiwe?

Yigcine ivalwe ngokuqinile, ipholile, yomile futhi ivikelwe ekukhanyeni, umswakama, umoya-mpilo kanye nezinto ezikhipha i-oxidizing. Landela imibandela yokugcina ephrintiwe kumkhiqizo onikeziwe.

Ingabe isixazululo se-aqueous glutathione sizinzile?

Izisombululo ze-GSH zingangena ku-GSSG. Lungiselela izixazululo zintsha ngaphandle kwalapho idatha yokuzinza eqinisekisiwe isekela isikhathi sokulondoloza esichaziwe.

Imaphi amaphakheji atholakalayo?

Iphakethe lenqwaba elijwayelekile lingama-25 kg isigubhu ngasinye esinama-liner angaphakathi amelana nomswakama. Amaphakheji amancane angaxoxwa ngesikhathi sokucaphuna.

Ingabe i-AOZUN inganikeza isampula kanye ne-COA?

Ukutholakala kwesampula kanye nemibhalo kungaxoxwa ngesikhathi sekhotheshini. Faka ibanga lakho, i-GSSG, i-microbiological nezidingo zokulawula embuzweni.

Cela I-Quote Eyehlisiwe ye-L-Glutathione

Xhumana ne-AOZUN ukuze uthole amanani ancishisiwe e-L-glutathione, imininingwane, ukupakishwa kanye nolwazi lokuthekelisa.

Sithumelele izinga lakho elidingekayo, i-assay, umkhawulo we-GSSG, isicelo, ubuningi, ukupakishwa, indawo kanye nezidingo zemibhalo. Ithimba lethu lizobuyekeza isicelo futhi liqinisekise ukucaciswa kwezentengiso okufanele.