Ethyl Acetoacetate (EAA)

Ethyl acetoacetate (EAA) is a classic β-keto ester and one of the most versatile building blocks in organic synthesis. Thanks to its active methylene group flanked by two carbonyl functions, EAA readily undergoes Knoevenagel condensations, Michael additions, and acylation reactions, making it indispensable in pharmaceutical intermediates, agrochemical synthesis, and flavor & fragrance formulations.

Technical Specifications

Packaging & Storage

• Net weight 200kg drum or 1000kg IBC Tank.

• Store in a cool, dry, well-ventilated area away from strong oxidizers, strong bases, and heat sources.

Key Applications of Ethyl Acetoacetate (EAA)

Pharmaceutical Intermediates

Core starting material for the synthesis of APIs

Agrochemicals

Used in the production of modern herbicides, fungicides, and insecticides (e.g., pyrazole and triazole derivatives)

Flavor & Fragrance

Imparts fruity, rum-like, and cognac notes; GRAS status when produced under food-grade conditions

Dyes & Pigments

Precursor for azo dyes and heterocyclic pigment intermediates

Solvent & Specialty Chemicals

High-boiling, low-toxicity solvent for coatings and inks

Frequently Asked Questions (FAQs)

Q: What is the difference between Ethyl Acetoacetate and Methyl Acetoacetate?

A: Ethyl acetoacetate (EAA) has an ethyl ester group, while methyl acetoacetate (MAA) has a methyl ester. EAA is more commonly used industrially due to lower cost and easier handling. MAA is sometimes preferred in reactions requiring higher reactivity or lower boiling byproducts.

Q: Why does EAA smell fruity?

A: The characteristic sweet, fruity, rum-like odor comes from its enol tautomer and trace volatile impurities formed during storage.

Q: Is methyl pyruvate stable at room temperature?

A: It is stable when stored at 2–8 °C in a sealed container protected from light. At room temperature it slowly decomposes or polymerizes, especially if exposed to moisture or air.

Q: Can I use methyl pyruvate in food or cosmetic formulations?

A: Methyl pyruvate is FEMA GRAS (No. 2673) as a synthetic flavoring substance when used within FDA limits (21 CFR 172.515). For cosmetic use, confirm compliance with regional regulations (e.g., EU Cosmetics Regulation, China IECIC).

Q: What solvents is methyl pyruvate miscible with?

A: Fully miscible with ethanol, acetone, diethyl ether, dichloromethane, and most organic solvents. Limited solubility in water.

Where can I buy high-quality Ethyl Acetoacetate (EAA)?

You can contact us via Email mandy@aozunchem.com or WhatsApp +86-18452425579 for offers and bulk orders.

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