Allantoin

Allantoin CAS 97-59-6 is a premium, high-purity active ingredient widely used in skincare, cosmetics, and personal care formulations. Known for its exceptional soothing, moisturizing, and skin-regenerating properties, Allantoin (INCI: Allantoin) is a must-have multifunctional compound for modern beauty and dermatological products.

What Is Allantoin?

Allantoin is a naturally occurring compound (chemically a diureide of glyoxylic acid) with the molecular formula C₄H₆N₄O₃ and molecular weight 158.12 g/mol. It appears as a fine, white, odorless, crystalline powder. It is stable across a broad pH range (typically 4–8) and is recognized for its excellent compatibility with most cosmetic ingredients.

CAS Number: 97-59-6

EINECS: 202-592-8

Appearance: White crystalline powder

Purity: Typically ≥98–99% (USP grade available)

Solubility: Slightly soluble in water at room temperature (≈0.5–0.6 g/100 mL at 25°C), solubility increases significantly with gentle heating (up to ≈4 g/100 mL at 75°C); soluble in alkaline solutions.

Key Benefits of Allantoin in Skincare and Cosmetics

Allantoin delivers multiple clinically appreciated effects at low concentrations (recommended usage: 0.1%–2.0%):

• Powerful Moisturization & Humectant Action — Attracts and binds moisture to the skin, helping to increase water content and reduce dryness.

  
  

• Soothing & Anti-Irritant Properties — Calms redness, irritation, and inflammation; ideal for sensitive, post-procedure, or compromised skin barriers.

  
  

• Promotes Skin Regeneration & Wound Healing — Supports cell proliferation and tissue repair, helping to accelerate recovery from minor cuts, burns, scrapes, or acne marks.

  
  

• Keratolytic & Smoothing Effect — Gently promotes exfoliation of dead skin cells, improving skin smoothness, softness, and overall texture.

  
  

• Anti-Aging Support — Enhances skin radiance, minimizes the appearance of fine lines, and contributes to a rejuvenated, youthful look.

  
  

• Protective & Conditioning — Recognized as a skin protectant; counteracts potential drying effects from other ingredients (alcohols, surfactants, etc.).

  
  

Common applications include:

• Facial creams, lotions, and moisturizers

• Anti-aging serums and eye creams

• Sun care and after-sun products

• Acne treatments and scar-fading formulas

• Baby care, diaper rash creams, and sensitive skin products

• Shampoos, conditioners, scalp treatments

• Shaving creams, aftershaves, and oral care (toothpastes, mouthwashes)

  
  

Why Formulators Choose Allantoin

• Effective at very low concentrations

• Non-irritating and suitable for all skin types, including sensitive and reactive skin

• Stable and easy to incorporate (add to aqueous phase with mild heating or prolonged stirring)

• Multifunctional — combines hydration, soothing, and healing in one ingredient

• Globally accepted in cosmetic and OTC pharmaceutical formulations

  
  

Frequently Asked Questions (FAQs)

Is Allantoin natural or synthetic?

Allantoin can be derived from natural sources (e.g., comfrey plant) or produced synthetically. Most cosmetic-grade Allantoin today is high-purity synthetic, ensuring consistency, safety, and absence of impurities.

Is Allantoin safe for sensitive skin?

Yes. Allantoin is widely regarded as non-irritating, gentle, and well-tolerated, even on sensitive, damaged, or post-procedural skin. It is commonly used in products designed for babies and reactive skin types.

What is the recommended usage level of Allantoin?

Typical effective concentrations range from 0.1% to 2.0%. Most formulations use 0.2%–0.5% for excellent soothing and moisturizing benefits.

Can Allantoin help with acne scars or wound healing?

Yes. Allantoin promotes healthy cell turnover and tissue regeneration, helping to fade the appearance of minor acne marks, burns, cuts, and other skin imperfections over time.

Does Allantoin have anti-aging benefits?

Allantoin supports smoother, softer, and more hydrated skin, which can contribute to a more youthful appearance and reduced visibility of fine lines.

Is Allantoin compatible with other active ingredients?

Yes, it is highly compatible with most cosmetic ingredients, including vitamins, acids (at appropriate pH), peptides, and surfactants.

How should Allantoin be added to formulations?

Dissolve in the water phase with gentle heating (around 50–60°C) or under prolonged stirring at room temperature. Avoid high oil phases as solubility in oils is very low.

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