N-Methylmorpholine (NMM)

N-Methylmorpholine (NMM) is a versatile cyclic tertiary amine and aprotic solvent widely used as a base catalyst, pH regulator, and intermediate in pharmaceutical, agrochemical, and polyurethane industries. Thanks to its moderate basicity (pKa of conjugate acid≈7.4) and excellent solubility in both water and organic solvents, NMM is the preferred alternative to triethylamine (TEA) and N,N-dimethylaminopyridine (DMAP) in many sensitive reactions.

Technical Specification

Packaging and Storage

• 180kgs galvanized iron drum, 14.4MT/FCL with pallets.

• Store in cool, well-ventilated area away from strong oxidizers and acids.

Applications of N-Methylmorpholine (NMM)

Peptide Synthesis:

Industry-standard base for solid-phase peptide synthesis (SPPS), especially in Fmoc/tBu strategies. Preferred coupling activator when used with HATU, HBTU, PyBOP, and COMU.

Pharmaceutical Intermediates:

Key solvent and catalyst in the production of antibiotics (e.g., cefepime, linezolid), oncology drugs, and beta-lactam derivatives.

Polyurethane Catalysts:

Blowing catalyst in flexible and rigid PU foams; offers lower odor than triethylamine.

Agrochemicals:

Used in the synthesis of herbicides, fungicides, and insecticides.

Semiconductor & Electronics:

High-purity grade used as photoresist stripper and cleaning agent.

Corrosion Inhibitors & Extraction:

Component in acid gas treatment (H₂S/CO₂ removal) and metal extraction processes.

Frequently Asked Questions (FAQs)

Q: What is the difference between N-Methylmorpholine (NMM) and 4-Methylmorpholine?

A: They are the same compound. "N-Methylmorpholine" and "4-Methylmorpholine" are synonymous IUPAC names (CAS 109-02-4).

Q: Can NMM replace triethylamine (TEA) directly in my reaction?

A: In most cases yes (1:1 molar ratio). NMM provides similar basicity with significantly lower odor, better solubility in water, and reduced side reactions in peptide coupling.

Q:Does N-Methylmorpholine (NMM) react with CO₂ in air?

A:Yes, it slowly absorbs CO₂ forming a crystalline carbamate salt. Use nitrogen blanketing for long-term storage of opened containers.

Q:What is the recommended storage condition?

A:Store in a cool, well-ventilated area away from sources of ignition and strong acids. Keep containers tightly closed under inert gas when possible.

Where can I buy high-quality N-Methylmorpholine (NMM)

You can contact us via E-mail mandy@aozunchem.com or WhatApp +86-18452425579 for offers and bulk orders.

AUTHENTICATION CERTIFICATE