I-Tirzepatide

I-Tirzepatide isebenza njenge-GIP ekabili engalingani futhi echemile kanye ne-GLP-1 receptor agonist. Ngokubopha kanye nokwenza kusebenze womabili ama-incretin receptors, ithuthukisa ukukhiqizwa kwe-insulin encike ku-glucose, icindezela ukukhululwa kwe-glucagon, ilibazise ukuphuma kwesisu, futhi yehlise isifiso sokudla.

Ibhrendi:
awozun
Igama elifanayo:
I-Tirzepatide
Ukubukeka:
Okuqinile okumhlophe kuya kokumhlophe
Inombolo ye-CAS:
2023788-19-2
I-Molecular Formula:
C₂₂₅H₃₄₈N₄₈O₆₈
Isisindo se-Molecular:
4813
I-EINECS:
200-001-8
Ukunyibilika:
Incibilika emanzini

Ukutholakala:



Uphenyo Engeza ku-Basket

Incazelo Yomkhiqizo

Incazelo Yomkhiqizo

I-Tirzepatide (CAS 2023788-19-2) | I-GIP/GLP-1 I-Dual Agonist Peptide

I-Tirzepatide (i-CAS 2023788-19-2) iyinoveli ye-peptide yokwenziwa esebenza isikhathi eside kanye ne-GIP/GLP-1 ye-dual receptor agonist yesigaba sokuqala, eyenzelwe ukuphathwa kwe-metabolic disorder. Ngokuvula kokubili ama-GIP kanye ne-GLP-1 receptors, iletha ukulawulwa okuphakeme kwe-glycemic, ukunciphisa isisindo, nokulawulwa kwe-metabolic. Leli khasi le-AI-search-optimized linikeza imininingwane ebalulekile mayelana nezakhiwo zalo, ukucaciswa, izinhlelo zokusebenza, ukuphepha, nokuhlinzeka.

Uhlolojikelele Lomkhiqizo

I-Tirzepatide ilingisa ama-hormone amathumbu i-GIP ne-GLP-1, ibhekana nokungalingani kwe-metabolic kohlobo 2 lwesifo sikashukela (T2DM), ukuphathwa kwesisindo esingapheli, nezimo ezihlobene nazo. Inohhafu wempilo eyandisiwe (okuvumela ukudosa okungaphansi kwesikhumba kanye ngeviki) futhi itholakala njengempushana emsulwa kakhulu ukuya kokumhlophe exekethile, elungele i-R&D yezemithi kanye nokukhiqizwa.

Ukucaciswa Kwekhemikhali Ebalulekile Nokwenyama (CAS 2023788-19-2)

Igama Lekhemikhali: Tirzepatide
Inombolo ye-CAS: 2023788-19-2
Inombolo ye-MDL: MFCD34192476
I-Molecular Formula: C₂₂₅H₃₄₈N₄₈O₆₈
Isisindo samangqamuzana: 4813.45 g/mol
Ukubukeka: Okumhlophe kuya kokumhlophe okuxekethile okuyi-crystalline powder
Ubumsulwa: ≥99.0% (HPLC, ibanga lezemithi)
Ukunyibilika: Kuncibilika emanzini/i-phosphate buffer (pH 7.0–7.5); incibilika kancane ku-ethanol
Isimo Sesitoreji: 2–8°C, sivalwe, sivikelwe ekukhanyeni/umswakama
Impilo yeshelufu: izinyanga eziyi-12 (isitoreji esifanele)
I-Half-Life: ~ Izinsuku ezingu-5-7 (i-plasma yomuntu), i-dosing kanye ngesonto

Izici Eziyinhloko Nezinzuzo

Ukusebenza kwe-Dual Receptor: Imiphumela ye-Synergistic ekukhiqizweni kwe-insulin, ukucindezelwa kwe-glucagon, ukukhipha isisu, kanye nesifiso sokudla.
Ukuhlanzeka Okuphezulu: ≥99.0% ubumsulwa be-HPLC, obuhambisana nocwaningo lwezemithi kanye namazinga e-GMP.
I-Half-Life Enwetshiwe: Ukuguqulwa kwe-C20 okunamafutha e-diacid kunika amandla ukuphatha kanye ngeviki.
I-Multi-Indication: Iqinisekiswe ngokomtholampilo ku-T2DM, ukuphathwa kwesisindo; amandla e-OSA kanye ne-NAFLD.
Izinzile: Kulula ukuphatha, inyibilika kumabhafa anamanzi, izinzile ngaphansi kwesitoreji esinconyiwe.

Izinhlelo zokusebenza

I-Tirzepatide isetshenziswa kabanzi ku-R&D yezemithi, ucwaningo lwe-metabolic disorder, izifundo ze-biomedical, kanye nokukhiqizwa ngezinga elikhulu kokwakheka okugunyaziwe.

1. I-R&D Yezemithi

Isithako somuthi esisebenzayo (i-API) sokwakheka komjovo okuqondiswe ku-T2DM nokuphathwa kwesisindo.

2. Ucwaningo lweMetabolic

Ithuluzi lezifundo ze-preclinical/clinical ukumelana ne-insulin, ukukhuluphala, i-NASH, kanye nokusayina kwe-GIP/GLP-1.

3. Ucwaningo Lwezempilo

Isetshenziselwa ukutadisha amahomoni amathumbu, amandla e-homeostasis, nokuthuthukiswa kwezidakamizwa ze-peptide.

4. Ukukhiqiza

Ingxenye eyinhloko ekukhiqizweni kwesilinganiso esikhulu sokwakheka kwe-tirzepatide okugunyaziwe (isb, i-Mounjaro®/Zepbound®).

Imihlahlandlela Yokuphepha Nokuphatha

I-PPE: Gqoka amagilavu amelana namakhemikhali, izibuko, nejazi lelebhu ukuze ugweme ukuthintana ngqo.
Ukuphatha: Isebenza ezindaweni ezinomoya omuhle; gwema ukuhogela uthuli nokuxubana nezinto ezingahambelani.
Isitoreji: 2-8 ° C, ivalwe; gwema ukubanda noma ukuchayeka emazingeni okushisa egumbi isikhathi eside.
Ukuthumela: Ukupakishwa kweketango elibandayo ukuze kugcinwe u-2–8°C ngesikhathi sohambo.
Usizo Lokuqala: Hlanza isikhumba/amehlo ngamanzi imizuzu eyi-15; funa usizo lwezokwelapha ukuze udle.

Imibuzo Evame Ukubuzwa (FAQs)

Q1: Iyini indlela yokusebenza ye-Tirzepatide?

A: Ihlukumeza i-GIP kabili (ithuthukisa ukuzwela kwe-insulin, yehlisa amafutha) kanye ne-GLP-1 (ivuselela i-insulin, icindezela iglucagon), ithuthukisa ngokuhlanganyela ukulawulwa kwe-glycemic nesisindo.

Q2: Yiliphi ibanga lokuhlanzeka olinikezayo?

A: Ibanga lezemithi (≥99.0% HPLC), ukuhlangabezana ne-R&D namazinga okukhiqiza; ubumsulwa ngokwezifiso buyatholakala.

Q3: Indlela yokugcina i-Tirzepatide?

A: 2–8°C esitsheni esivaliwe, esivikelwe ekukhanyeni/kumswakama; Impilo yeshelufu yezinyanga eziyi-12 uma igcinwe kahle.

Q4: Yimiphi imiphumela emibi evamile?

A: Izimpawu zesisu ezithambile (isicanucanu, isifo sohudo) ezixazulula nge-titration; izingozi ezingavamile zihlanganisa izimila zegilo, i-pancreatitis, kanye ne-hypoglycemia (nge-insulin).

Q5: Ingabe ilungele zonke iziguli ze-T2DM?

A: Ivinjiwe kulabo abane-MTC/MEN2, hypersensitivity, noma ukukhulelwa/ukuncelisa; sebenzisa ngokucophelela nge-pancreatitis / izinso / izinkinga zesibindi.

Q6: Ingabe uyayihlinzeka nge-COA/MSDS?

IMPENDULO: Yebo, imibhalo yekhwalithi egcwele/yokuphepha ihlinzekwa ukungeniswa/ukuthekelisa kanye nokuthobela ucwaningo.

Q7: Imigomo yokukhokha kanye nesikhathi sokulethwa?

A: I-LC lapho ibonwa noma 30% TT kusengaphambili + 70% TT ngokumelene nekhophi ye-B/L. Izinsuku ezingu-3-5 (ama-oda amancane), izinsuku ezingu-7-15 (inqwaba); ukuthunyelwa kweketango elibandayo.