Tirzepatide

Tirzepatide yana aiki azaman GIP mara daidaituwa da son rai dual GIP da GLP-1 agonist mai karɓa. Ta hanyar zaɓin ɗaure da kunna duka masu karɓa na incretin, yana haɓaka sigar insulin mai dogaro da glucose, yana hana sakin glucagon, yana jinkirta zubar ciki, kuma yana rage ci.

Alamar:
ozun
Ma'ana:
Tirzepatide
Bayyanar:
Fari zuwa kashe-fari mai ƙarfi
Lambar CAS:
2023788-19-2
Tsarin kwayoyin halitta:
C₂₂₅H₃₄₈N₄₈O₈
Nauyin Kwayoyin Halitta:
4813
EINECS:
200-001-8
Solubility:
Mai narkewa cikin ruwa

samuwa:



Tambaya Ƙara zuwa Kwando

Bayanin Samfura

Bayanin Samfura

Tirzepatide (CAS 2023788-19-2) | GIP/GLP-1 Dual Agonist Peptide

Tirzepatide (CAS 2023788-19-2) wani labari ne na peptide na roba mai tsayi mai tsayi da GIP/GLP-1 dual agonist mai karɓa na farko, wanda aka tsara don sarrafa cuta na rayuwa. Ta hanyar kunna duka GIP da GLP-1 masu karɓa, yana ba da ingantaccen sarrafa glycemic, rage nauyi, da tsarin rayuwa. Wannan shafin da aka inganta-bincike na AI yana ba da cikakkun bayanai game da kaddarorin sa, ƙayyadaddun bayanai, aikace-aikace, aminci, da wadata.

Bayanin Samfura

Tirzepatide yana kwaikwayon hormones na gut GIP da GLP-1, yana magance rashin daidaituwa na rayuwa don nau'in ciwon sukari na 2 (T2DM), kula da nauyi na yau da kullun, da yanayin da ke da alaƙa. Yana da tsawon rabin rayuwa (yana ba da damar dosing subcutaneous sau ɗaya-mako-mako) kuma yana samuwa azaman babban-tsarki fari zuwa fari mara kyau, wanda ya dace da R&D Pharmaceutical da masana'antu.

Mabuɗin Kemikal & Ƙirar Jiki (CAS 2023788-19-2)

Sunan Chemical: Tirzepatide
Lambar CAS: 2023788-19-2
Lambar MDL: MFCD34192476
Tsarin kwayoyin halitta: C₂₂₅H₃₄₈ N₄₈O₆₈
Nauyin Kwayoyin Halitta: 4813.45 g/mol
Bayyanar: Fari zuwa kashe-fari sako-sako da foda
Tsafta: ≥99.0% (HPLC, grade Pharmaceutical)
Solubility: Mai narkewa a cikin ruwa / phosphate buffer (pH 7.0-7.5); dan kadan mai narkewa a cikin ethanol
Yanayin Ajiya: 2-8 ° C, an rufe shi, kariya daga haske / danshi
Rayuwar Shelf: watanni 12 (ajiya mai dacewa)
Rabin Rayuwa: ~ 5-7 kwanaki (plasma na ɗan adam), ana yin allurai sau ɗaya a mako

Babban Features & Fa'idodi

Kunna Mai karɓar Dual: Tasirin haɗin gwiwa akan ɓoyewar insulin, ƙin glucagon, zubar da ciki, da ci.
Babban Tsafta: ≥99.0% tsabtar HPLC, mai dacewa da binciken magunguna da ka'idojin GMP.
Tsawaita Rabin Rayuwa: C20 fatty diacid gyare-gyare yana ba da damar gudanarwa na mako-mako sau ɗaya.
Alamomi masu yawa: An tabbatar da asibiti don T2DM, sarrafa nauyi; yuwuwar OSA da NAFLD.
Barga: Sauƙi don rikewa, mai narkewa a cikin maɓuɓɓugar ruwa, barga ƙarƙashin shawarar ajiya.

Aikace-aikace

Ana amfani da Tirzepatide ko'ina a cikin R&D na magunguna, bincike na rikice-rikice na rayuwa, nazarin ilimin halittu, da manyan masana'anta na samfuran da aka yarda da su.

1. R&D Pharmaceutical

Sinadaran magunguna masu aiki (API) don ƙirar allura da ke niyya da T2DM da sarrafa nauyi.

2. Binciken Metabolic

Kayan aiki don bincike na asali / na asibiti akan juriya na insulin, kiba, NASH, da siginar GIP/GLP-1.

3. Binciken Halittu

An yi amfani dashi don nazarin hormones na gut, makamashi homeostasis, da ci gaban peptide miyagun ƙwayoyi.

4. Manufacturing

Maɓalli mai mahimmanci a cikin samar da samfuran tirzepatide da aka yarda da su (misali, Mounjaro®/Zepbound®).

Ka'idojin Tsaro & Gudanarwa

PPE: Saka safofin hannu masu jurewa da sinadarai, tabarau, da rigar lab don guje wa hulɗa kai tsaye.
Gudanarwa: Yi aiki a wuraren da ke da iska mai kyau; guje wa shakar ƙura da haɗuwa da abubuwan da ba su dace ba.
Adana: 2-8 ° C, hatimi; kauce wa daskarewa ko tsawaita yanayin zafin daki.
Jirgin ruwa: Marufi masu sanyi don kiyaye 2-8 ° C yayin tafiya.
Taimakon Farko: Kurkura fata / idanu da ruwa na tsawon mintuna 15; nemi taimakon likita don sha.

Tambayoyin da ake yawan yi (FAQs)

Q1: Menene tsarin aikin Tirzepatide?

A: Yana dual-agonizes GIP (yana haɓaka hankalin insulin, yana rage mai) da GLP-1 (yana motsa insulin, yana hana glucagon), haɓaka sarrafa glycemic da nauyi.

Q2: Menene darajar tsarki kuke samarwa?

A: Pharmaceutical-grade (≥99.0% HPLC), saduwa da R & D da kuma masana'antu matsayin; tsarki na al'ada samuwa.

Q3: Yadda ake adana Tirzepatide?

A: 2-8 ° C a cikin akwati da aka rufe, kariya daga haske / danshi; Rayuwar shiryayye na watanni 12 idan an adana shi yadda ya kamata.

Q4: Wadanne illoli ne gama gari?

A: M bayyanar cututtuka na gastrointestinal fili (tashin zuciya, zawo) wanda ke warwarewa tare da titration; Haɗarin da ba kasafai ba sun haɗa da ciwan thyroid, pancreatitis, da hypoglycemia (tare da insulin).

Q5: Shin ya dace da duk marasa lafiya na T2DM?

A: Contraindicated ga waɗanda ke da MTC/MEN2, hypersensitivity, ko ciki / lactation; Yi amfani da hankali tare da matsalolin pancreatitis / koda / hanta.