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The rubber industry and pharmaceutical field of thiourea

Views: 0     Author: Site Editor     Publish Time: 2024-04-01      Origin: Site


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Thiourea, also known as thiourea, is an organic compound containing sulfur and urea functional groups, with the chemical formula CS (NH2) 2. It is a white to light yellow crystalline solid that is easily soluble in water and alcohols at room temperature, but has lower solubility in ethers. Thiourea has multiple chemical reactivity, therefore it has a wide range of applications in industry and scientific research.


The importance of thiourea in the rubber industry is reflected in its role as a vulcanizing agent and promoter for rubber. During the vulcanization of rubber, thiourea can react with the double bond in the rubber molecule to form a cross-linked structure, thereby improving the elasticity, wear resistance and aging resistance of rubber. In addition, thiourea can also serve as a promoter in rubber processing, accelerating the vulcanization reaction, shortening the production cycle, and improving production efficiency.


In the pharmaceutical field, thiourea is used as an intermediate in the synthesis of various drugs due to its unique biological activity. Thiourea and its derivatives have various pharmacological effects such as antibacterial, anti-inflammatory, and anti-tumor, making them of great value in the development of new drugs and the improvement of existing drugs.


These characteristics of thiourea make it play an indispensable role in the rubber industry and pharmaceutical field, which is of great significance for promoting technological progress and product innovation in related industries. With the development of technology and changes in market demand, the application fields and mechanisms of thiourea will continue to expand, bringing more benefits to industrial production and human health.


Chemical properties of thiourea

physical property

Appearance: Thiourea typically appears as a white to light yellow crystalline solid with a glossy appearance.


Density: The density of thiourea is approximately 1.41g/cm ⊃3;


Melting point: The melting point of thiourea is between 176 and 178 ℃.

Solubility: Thiourea has a lower solubility in water, but can dissolve in hot water; Easily soluble in ethanol, slightly soluble in ether.


Refractive index: The refractive index of thiourea is approximately 1.654.


Flash point: The flash point of thiourea is 66.8 ℃.


Critical pressure: The critical pressure of thiourea is 8.23 MPa.


chemical property


Chemical reactivity: Thiourea can react with various chemical substances, such as hydrogen sulfide, calcium cyanamide, etc., to form thiourea.


Acidity: Thiourea is a weakly acidic compound that can react with bases to form salts.

Thermal stability: Thiourea is stable when heated, but may decompose at high temperatures.


Toxicity: Thiourea has certain toxicity, with acute toxicity LD50 of 125mg/kg (oral in rats) and 100mg/kg (abdominal in mice).


Ecotoxicity: Thiourea is toxic to aquatic organisms and may cause long-term adverse effects in aquatic environments.


security information


Operation precautions: When operating thiourea, appropriate safety measures should be taken, such as closed operation, local ventilation, wearing protective clothing and gloves, etc.


First aid measures: After skin contact with thiourea, rinse thoroughly with soap water and water immediately; After eye contact, rinse with flowing water or physiological saline and seek medical attention; After inhaling thiourea, one should quickly leave the scene to a place with fresh air and keep the respiratory tract unobstructed; After ingesting thiourea, one should drink sufficient warm water, induce vomiting, and seek medical attention.


Fire fighting measures: harmful nitrogen oxide and sulfur oxide gas may be produced when thiourea burns. Water, foam, carbon dioxide, sand and other methods shall be used to extinguish the fire.


Application of Thiourea in Rubber Industry


As a vulcanization promoter


During the rubber vulcanization process, thiourea serves as an effective promoter that can accelerate the chemical reaction between rubber and vulcanizing agents, thereby shortening vulcanization time and improving production efficiency. Thiourea can promote the formation of cross-linking network by reacting with double bonds in rubber molecules, which helps to improve the elasticity, wear resistance and anti-aging properties of rubber.



Improve vulcanization efficiency and product quality


The use of thiourea can significantly improve the vulcanization efficiency, enabling rubber products to achieve the required physical and chemical properties in a short period of time. This efficiency improvement not only reduces production time and costs, but also helps to improve product consistency and reliability. In addition, thiourea can also improve the processing performance of rubber, making it easier to shape and process.


The environmental advantages of thiourea


The environmental advantage of thiourea lies in its production process and minimal impact on the environment during use. Compared with traditional vulcanization accelerators, thiourea generates less wastewater and exhaust gas in the production process, which helps to reduce environmental pollution. In addition, the decomposition products of thiourea are relatively harmless and will not cause long-term harm to the ecosystem.



Against the backdrop of increasingly strict environmental requirements, the environmental characteristics of thiourea make its application in the rubber industry more attractive. By using thiourea as a vulcanization promoter, rubber production enterprises can not only improve production efficiency and product quality, but also respond to environmental policies and achieve sustainable development.




The application of thiourea in the rubber industry has demonstrated its important role as a vulcanization promoter. It not only improves vulcanization efficiency and product quality, but also has significant environmental advantages. With the strengthening of environmental regulations and technological progress, thiourea is expected to play a greater role in the future rubber industry, contributing to achieving greener and more efficient rubber production.


The application of thiourea in the pharmaceutical field


Drug synthesis intermediates


Thiourea, as an important organic chemical intermediate, plays a crucial role in the synthesis of various drugs. Due to the presence of active sulfur atoms and amino groups in thiourea molecules, they can participate in various chemical reactions such as nucleophilic substitution, acylation, condensation, etc., thus synthesizing compounds with specific biological activities. Thiourea has a wide range of applications in the synthesis of anti-thyroid drugs, antifungal drugs, anti-tumor drugs, and so on.


Medications for treating hyperthyroidism


Thiourea drugs are one of the main drugs for treating hyperthyroidism. These drugs control symptoms of hyperthyroidism by inhibiting the activity of thyroid peroxidase and reducing the synthesis of thyroid hormones. Common thiourea based anti thyroid drugs include propylthiouracil (PTU) and methylthiouracil (MMI), both of which are derivatives based on thiourea.


Other potential drug development


The structural units of thiourea are widely present in many bioactive molecules, thus having great potential in the development of new drugs. Thiourea compounds have been studied in various fields such as anti-inflammatory, antibacterial, antiviral, and anti-tumor. With the deepening understanding of the structure-activity relationship of thiourea compounds, more new drugs based on thiourea structures may be developed in the future.


Market prospects of thiourea


Market demand analysis

Rubber industry: Thiourea serves as a vulcanization promoter in the rubber industry, helping to improve the elasticity and wear resistance of rubber. With the increase in global rubber consumption, the demand for thiourea has also increased.


In the agricultural field, thiourea can be used as a nitrogen fertilizer to provide the nitrogen element required for plant growth, while also having bactericidal effects, helping to prevent and control crop diseases and pests.


Chemical industry: Thiourea is used as a raw material in the chemical industry to synthesize various chemicals, such as dyes, resins, etc.


Electronics industry: Electronic grade thiourea has important applications in electronic electroplating fields such as electroplating solutions and printed circuit boards. With the rapid development of the electronics industry, the demand for high-purity thiourea continues to grow.


Development trends


Technological innovation: With the advancement of technology, the production technology of thiourea continues to improve, resulting in improved product quality and performance, which helps to expand the application scope of thiourea in various fields.


Environmental trends: The increasing global environmental awareness has led to an increasing demand for environmentally friendly chemicals. Thiourea, as a relatively environmentally friendly compound, is expected to gain more market opportunities while meeting environmental standards.


Emerging application areas: The application of thiourea in emerging fields such as medicine and agriculture is also constantly expanding, bringing more opportunities to the thiourea market.


Potential challenges


Raw material price fluctuations: The production cost of thiourea is greatly affected by raw material prices, and price fluctuations may lead to unstable production costs, affecting market supply.


Market competition: There is a certain degree of competition in the thiourea market, mainly from domestic and foreign manufacturers. Enterprises need to enhance their competitiveness in product quality, technological innovation, marketing, and other aspects.


Policy environment: As a chemical product, thiourea is constrained by environmental regulations, safety production standards, and other policies. Enterprises need to comply with production regulations, strengthen environmental governance, and ensure product quality and production safety.


International trade friction: Changes in the international trade environment may affect the import and export of thiourea. Enterprises need to closely monitor international trade policies and flexibly adjust their business strategies.




Comprehensive evaluation of thiourea in two major fields

Rubber industry:


Thiourea, as a rubber accelerator, can effectively improve vulcanization efficiency and product quality, and is an indispensable chemical in rubber production.

With the growth of global rubber demand, the application of thiourea in the rubber industry will continue to expand, especially in tire manufacturing, rubber hoses, rubber shoes and other products.


The strengthening of environmental regulations has driven the demand for environmentally friendly rubber additives, and thiourea, as a relatively environmentally friendly chemical, is expected to be more widely used in the rubber industry.


Agriculture sector:


Thiourea, as a nitrogen fertilizer and fungicide, is of great significance in promoting crop growth and increasing agricultural yield.


In the context of global food security and sustainable agricultural development, the application of thiourea in the agricultural field will be given more attention.


The multifunctionality of thiourea gives it the potential to replace traditional chemicals in the agricultural field, helping to reduce negative environmental impacts.


Outlook for future development


Technological innovation: It is expected that the production technology of thiourea will continue to improve in the future, improving production efficiency and product quality, while reducing costs and environmental impact.


Market expansion: With the rise of emerging markets and the deepening of existing markets, the global market demand for thiourea is expected to continue to grow.


Environmental trend: The demand for environmentally friendly chemicals will continue to rise globally, and thiourea, as an environmentally friendly chemical, is expected to further expand its market share.


Policy support: With the increasing attention of governments around the world to environmental protection and sustainable development, thiourea may receive more policy support and market incentives.

Diversified applications: The application of thiourea in other fields such as medicine, electronics, and chemical industry will continue to expand with technological progress, providing new impetus for its market growth.


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