Pimobendan

Product Overview

Pimobendan (C₂₀H₁₈N₄O₄) is a selective phosphodiesterase III inhibitor and calcium sensitizer widely used in veterinary cardiology. It is commonly prescribed to treat congestive heart failure in dogs, improving cardiac output, reducing symptoms of heart failure, and enhancing quality of life.

Pimobendan is valued for its dual mechanism of action, combining positive inotropic effects with vasodilation, making it a cornerstone therapy for canine heart disease management.

Key Product Identification

• Product Name: Pimobendan

• Synonyms: Vetmedin, Pimobendan Hydrochloride (for hydrochloride salt)

• Chemical Formula: C₂₀H₁₈N₄O₄

• CAS Number: 20335-16-4

• Molecular Weight: 386.39 g/mol

• Appearance: White to off-white crystalline powder

• Odor: Odorless

• Solubility: Slightly soluble in water; soluble in organic solvents such as methanol and ethanol

Chemical & Physical Properties

Manufacturing & Quality Control

Pimobendan is synthesized via multi-step organic synthesis under GMP conditions. Quality control ensures:

• High chemical and pharmaceutical purity

• Low residual solvents and impurities

• Compliance with veterinary pharmaceutical regulations

Each batch undergoes HPLC assay, moisture analysis, and appearance inspection to guarantee reliability and safety.

Applications of Pimobendan

Veterinary Cardiology

• Used to manage congestive heart failure (CHF) in dogs, particularly myocardial insufficiency and valvular heart disease.

• Improves cardiac contractility, stroke volume, and exercise tolerance.

• Reduces clinical symptoms such as lethargy, coughing, and edema.

Pharmaceutical Research

• Applied as a research compound in studies of cardiac physiology and drug development.

• Investigated for its mechanistic effects on calcium sensitization and PDE inhibition.

Formulation Applications

• Incorporated into veterinary oral tablets, capsules, and compounded formulations.

• Compatible with standard excipients for stable and bioavailable dosage forms.

Packaging & Logistics

• Standard Packaging:

• 100 g, 500 g, 1 kg pharmaceutical-grade powder in sealed amber HDPE containers

• Custom packaging available upon request

• Storage Conditions:

• Store in a cool, dry, and dark environment

• Keep containers tightly closed

• Avoid high temperature, humidity, and direct sunlight

Safety & Handling

• Handle with standard laboratory or pharmaceutical precautions

• Avoid inhalation of powder and prolonged skin contact

• Use appropriate PPE including gloves, goggles, and lab coat

• Consult the Safety Data Sheet (SDS/MSDS) for detailed handling, storage, and emergency instructions

Regulatory & Documentation

Available upon request:

• COA (Certificate of Analysis)

• SDS / MSDS

• TDS (Technical Data Sheet)

• Veterinary pharmaceutical compliance and GMP documentation

Why Choose Our Pimobendan?

• ✔ High pharmaceutical-grade purity (≥99%)

• ✔ Suitable for veterinary formulations and research applications

• ✔ Flexible packaging and bulk supply options

• ✔ Export-ready documentation and regulatory support

• ✔ Technical guidance for formulation and dosage development

Frequently Asked Questions (FAQ)

Q1: What is Pimobendan used for?

It is primarily used to treat congestive heart failure in dogs, improving cardiac output and reducing CHF symptoms.

Q2: Is Pimobendan soluble in water?

It is slightly soluble in water but soluble in organic solvents like methanol and ethanol.

Q3: Can you provide analytical and regulatory documents?

Yes, COA, SDS, TDS, and GMP compliance documents are available.

Q4: What is the typical minimum order quantity (MOQ)?

MOQ depends on packaging and regulatory requirements; please contact us for details.