I-Pimobendan

Uhlolojikelele Lomkhiqizo

I-Pimobendan (C₂₀H₁₈N₄O₄) iyisivimbeli esikhethiwe se-phosphodiesterase III kanye ne-calcium sensitizer esetshenziswa kabanzi kudokotela wezilwane . Ngokuvamile kunqunyelwe ukwelapha ukuhluleka kwenhliziyo ezinjeni ezinjeni , ukuthuthukisa ukuphuma kwenhliziyo, ukunciphisa izimpawu zokuhluleka kwenhliziyo, nokuthuthukisa izinga lokuphila..

I-Pimobendan ibaluleke kakhulu ngenxa yokusebenza kwayo okumbaxambili , ehlanganisa imiphumela emihle ye-inotropic ne-vasodilation , okwenza kube ukwelapha okuyisisekelo ekulawuleni isifo senhliziyo ye-canine..

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Ukuhlonza Umkhiqizo Obalulekile

• Igama lomkhiqizo: Pimobendan

• Amazwi afanayo: I-Vetmedin, i-Pimobendan Hydrochloride (ye-hydrochloride usawoti)

• I-Chemical Formula: C₂₀H₁₈N₄O₄

• Inombolo ye-CAS: 20335-16-4

• Isisindo se-Molecular: 386.39 g/mol

• Ukubukeka: I-crystalline powder emhlophe ukuya kokumhlophe

• Iphunga: Ayinaphunga

• Ukunyibilika: Incibilika kancane emanzini; I-soluble ku-organic solvents njenge-methanol ne-ethanol

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Chemical & Physical Properties

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Ukukhiqiza Nokulawula Ikhwalithi

I-Pimobendan ihlanganiswa nge- multi-step organic synthesis ngaphansi kwezimo ze-GMP . Ukulawulwa kwekhwalithi kuqinisekisa:

• Ukuhlanzeka okuphezulu kwamakhemikhali kanye nemithi

• Izincibilikisi ezinsalela eziphansi nokungcola

• Ukuhambisana nemithethonqubo yezokwelapha yezilwane

Iqoqo ngalinye lihlolwa i-HPLC, ukuhlaziywa komswakama, nokuhlolwa kokubukeka ukuze kuqinisekiswe ukwethembeka nokuphepha.

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Izicelo ze-Pimobendan

I-Veterinary Cardiology

• Isetshenziselwa ukuphatha ukuhluleka kwenhliziyo (CHF) ezinjeni , ikakhulukazi ukungasebenzi kahle kwe-myocardial nesifo senhliziyo se-valvular.

• Ithuthukisa ukuqina kwenhliziyo, ivolumu yokushaywa unhlangothi, nokubekezelela ukuvivinya umzimba.

• Yehlisa izimpawu zomtholampilo ezifana nokukhathala, ukukhwehlela, kanye ne-edema.

Ucwaningo Lwezemithi

• Kusetshenziswa njengenhlanganisela yocwaningo ezifundweni ze -cardiac physiology kanye nokuthuthukiswa kwezidakamizwa.

• Iphenyelwe imiphumela yayo yobuchwepheshe ekuzweleni kwe-calcium nokuvinjwa kwe-PDE.

Izicelo Zokwakha

• Kufakwe kumaphilisi omlomo wezilwane, amaphilisi, kanye nokwakheka okuhlanganisiwe.

• Ihambisana nama-excipients ajwayelekile amafomu omthamo ozinzile natholakala nge-bioavailable.

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Ukupakisha & Logistics

• Ukupakisha Okujwayelekile:

• 100 g, 500 g, 1 kg powder-grade powder ezitsheni ezivaliwe ze-amber HDPE

• Ukupakisha ngokwezifiso kuyatholakala uma ucela

• Imibandela Yesitoreji:

• Gcina endaweni epholile, eyomile, nemnyama

• Gcina iziqukathi zivaliwe ngokuqinile

• Gwema izinga lokushisa eliphezulu, umswakama, nokukhanya kwelanga okuqondile

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Ukuphepha Nokuphatha

• Phatha ngelabhorethri evamile noma izinyathelo zokuphepha zemithi

• Gwema ukuhogela impushana kanye nokuthinta isikhumba isikhathi eside

• Sebenzisa i-PPE efanele kufaka phakathi amagilavu, izibuko, nejazi laselabhu

• Bheka I- Safety Data Sheet (SDS/MSDS) ukuze uthole imininingwane eningiliziwe yokusingatha, ukugcinwa, kanye neziyalezo zezimo eziphuthumayo

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Ukulawula Nokubhaliwe

Itholakala ngesicelo:

• I-COA (Isitifiketi Sokuhlaziya)

• I-SDS / MSDS

• I-TDS (Ishidi Ledatha Yobuchwepheshe)

• Ukuthobela imithi yezilwane kanye nemibhalo ye-GMP

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Kungani Khetha I-Pimobendan Yethu?

• ✔ Ukuhlanzeka okuphezulu kwebanga lezemithi (≥99%)

• ✔ Ifanele ukwakhiwa kwezilwane kanye nezicelo zocwaningo

• ✔ Izinketho zokupakisha eziguquguqukayo kanye nokunikezwa kwenqwaba

• ✔ Amadokhumenti alungele ukuthumela ngaphandle kanye nokwesekwa kokulawula

• ✔ Isiqondiso sobuchwepheshe sokwakheka nokuthuthukiswa komthamo

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Imibuzo Evame Ukubuzwa (FAQ)

Q1: Isetshenziselwa ini i-Pimobendan?

Ngokuyinhloko isetshenziselwa ukwelapha ukuhluleka kwenhliziyo ezinjeni ezinjeni, ukuthuthukisa ukuphuma kwenhliziyo nokunciphisa izimpawu ze-CHF.

Q2: Ingabe i-Pimobendan iyancibilika emanzini?

Incibilika kancane emanzini kodwa incibilika kuzincibilikisi zemvelo njenge-methanol ne-ethanol.

Q3: Ungakwazi yini ukunikeza imibhalo yokuhlaziya neyokulawula?

Yebo, imibhalo ye-COA, SDS, TDS, kanye ne-GMP iyatholakala.

I-Q4: Yiliphi inani elijwayelekile le-oda elincane (MOQ)?

I-MOQ incike ezidingweni zokupakisha nezokulawula; sicela usithinte ukuze uthole imininingwane.