T-Butyl Bromoacetate

Tert-Butyl Bromoacetate, also known as t-Butyl Bromoacetate or Bromoacetic Acid tert-Butyl Ester, is a versatile organic compound widely used in chemical synthesis. This colorless liquid serves as an effective alkylating agent in various pharmaceutical and research applications. It is particularly valued for its role in producing intermediates for amino acids, peptides, and advanced materials like MRI contrast agents.

Technical Specifications

Packaging and Storage

• Net weight 250kg iron drum.

• Store in a tightly closed container in a cool, dry, well-ventilated area away from ignition sources and incompatible materials like strong oxidizers

Applications of Tert-Butyl Bromoacetate

Tert-Butyl Bromoacetate is a key reagent in organic synthesis due to its reactivity as an alkylating agent. Common applications include:

Pharmaceutical Intermediates:

Used in the synthesis of amino acids and peptide compounds, facilitating the creation of complex biomolecules.

Chelating Agents:

Essential for producing DO3A tris(t-Bu ester), a scaffold for bifunctional chelates in MRI contrast agents and diagnostic tools.

Polymer Functionalization:

Employed in atom transfer radical polymerization to synthesize nitrilotriacetic acid end-functionalized polystyrene.

Agrochemicals and Other Syntheses:

Serves as a building block in multi-step reactions for agrochemicals and specialized compounds, often involving reactions with amines or β-amino acids.

Research and Development:

Its high affinity for binding to amines makes it useful in biochemical studies and green synthesis methods.

This compound's versatility supports innovation in fields like medicine, materials science, and biotechnology.

Frequently Asked Questions (FAQs)

Q: What is Tert-Butyl Bromoacetate?

A: Tert-Butyl Bromoacetate is an organic ester with the formula C6H11BrO2, commonly used as an alkylating agent in chemical synthesis.

Q: What are the primary uses of Tert-Butyl Bromoacetate?

A: It is primarily used in synthesizing pharmaceutical intermediates, chelating agents for MRI contrast, and functionalized polymers.

Q: Is Tert-Butyl Bromoacetate safe to handle?

A: No, it is corrosive and flammable. Proper protective equipment and ventilation are required to minimize risks.

Q: How should Tert-Butyl Bromoacetate be stored?

A: Store in a sealed container in a cool, dry place away from heat and ignition sources.

Q: Can Tert-Butyl Bromoacetate be used in green chemistry applications?

A: Yes, it supports green preparation methods in synthesizing MRI contrast agents and other compounds.

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