Tert-Butyl Chloroacetate

Tert-Butyl Chloroacetate, also known as chloroacetic acid tert-butyl ester, is a versatile ester compound widely used in organic chemistry and industrial applications. With the chemical formula C6H11ClO2 and CAS number 107-59-5, this colorless liquid serves as a key building block in the synthesis of pharmaceuticals, agrochemicals, and specialty chemicals.

Technical Specifications

Packaging and Storage

• Net weight 200kg drum,16MT/20FCL with pallets.

• Store in a cool, well-ventilated warehouse, away from sources of ignition and heat. The storage temperature should not exceed 30℃. Protect from direct sunlight. Keep the container sealed and store separately from oxidants

Applications of Tert-Butyl Chloroacetate

Tert-Butyl Chloroacetate is a critical reagent in various chemical processes:

Pharmaceutical Synthesis:

Acts as an intermediate in the production of active pharmaceutical ingredients (APIs), particularly in the formation of glycine derivatives and peptide coupling agents.

Agrochemical Manufacturing:

Used in the synthesis of herbicides and pesticides, leveraging its chloroacetyl functionality for targeted molecular modifications.

Organic Chemistry Research:

Employed in laboratory settings for introducing chloroacetyl groups into molecules, facilitating reactions like nucleophilic substitution and deprotection.

Specialty Chemicals:

Serves as a precursor for surfactants, dyes, and polymers, where the tert-butyl group provides temporary protection during multi-step syntheses.

Its unique combination of reactivity and stability makes it a preferred choice for chemists aiming to optimize yield and selectivity in complex reactions.

Frequently Asked Questions (FAQs)

Q: What are the primary uses of Tert-Butyl Chloroacetate?

A: It is primarily used in synthesizing pharmaceutical intermediates, chelating agents for MRI contrast, and functionalized polymers.

Q: Is Tert-Butyl Chloroacetate soluble in water?

A: It is slightly soluble in water but highly soluble in organic solvents such as ethanol, acetone, and diethyl ether. This property makes it suitable for non-aqueous reaction environments.

Q: Is Tert-Butyl Chloroacetate hazardous?

A: Yes, it is flammable and can cause skin and eye irritation. Always handle with appropriate PPE and follow SDS guidelines.

Q: How should I store Tert-Butyl Chloroacetate?

A: Store in a tightly sealed container in a cool, dry, well-ventilated area away from heat and direct sunlight to maintain stability.

Contact Us

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