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4-Chlorobenzenesulfonyl Chloride

4-chlorobenzenesulfonyl chloride is a white prismatic crystal and an intermediate in the synthesis of pharmaceuticals. There are various traditional production processes for synthesizing 2-chlorobenzenesulfonyl chloride, and the main ones commonly used in industrial production both domestically and internationally are the excess chlorosulfonic acid method and the sulfur trioxide method.
  • White crystals

  • 98-60-2

  • C6H4Cl2O2S

  • 211.07

  • 202-685-3

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Product Description

4-Chlorobenzenesulfonyl Chloride


Product Overview


4-Chlorobenzenesulfonyl Chloride is an aromatic sulfonyl chloride widely used as a key intermediate in pharmaceutical, agrochemical, and fine chemical synthesis. Owing to its highly reactive sulfonyl chloride group, it is commonly employed in sulfonylation reactions for the preparation of sulfonamides, sulfonate esters, and functionalized aromatic compounds.


This compound is valued for its predictable reactivity and suitability for both industrial-scale production and laboratory research.




Key Product Identification


  • Product Name: 4-Chlorobenzenesulfonyl Chloride

  • Synonyms: p-Chlorobenzenesulfonyl Chloride

  • Chemical Formula: C₆H₄Cl₂O₂S

  • CAS Number: 98-60-2

  • Molecular Weight: 227.06 g/mol

  • HS Code: 29041000

  • Appearance: White to pale yellow crystalline solid

  • Odor: Pungent, characteristic sulfonyl chloride odor




Chemical & Physical Properties


Property Typical Value
Purity ≥ 98.0%
Physical State Solid
Reactivity Reacts readily with amines and alcohols
Solubility Soluble in most organic solvents
Moisture Sensitivity Moisture-sensitive

Typical values for industrial and export-grade material.




Manufacturing & Quality Control


4-Chlorobenzenesulfonyl Chloride is manufactured via controlled sulfonation and chlorination of chlorobenzene derivatives. Production is carried out under strictly monitored conditions to ensure consistent quality and performance.


Quality control includes:


  • Purity analysis (HPLC / GC)

  • Moisture and impurity control

  • Appearance and color inspection

  • Batch traceability

Complete quality documentation is supplied with each shipment.




Applications of 4-Chlorobenzenesulfonyl Chloride


Pharmaceutical Intermediates

Used in the synthesis of sulfonamide-based drug intermediates and API building blocks.


Agrochemical Manufacturing

Applied in the production of pesticide and herbicide intermediates requiring aromatic sulfonyl groups.


Fine Chemicals & Specialty Synthesis

Used in specialty chemical production, custom synthesis, and contract manufacturing.


Research & Development

Common reagent in organic chemistry laboratories for sulfonylation reactions.




Packaging & Logistics


  • Standard Packaging:

    • 25 kg fiber drum

    • 25 kg plastic drum

  • Custom Packaging: Available upon request

  • Storage Conditions:

    • Store in a cool, dry, well-ventilated area

    • Keep containers tightly sealed and protected from moisture




Safety & Handling


  • Corrosive and moisture-reactive chemical

  • Avoid contact with skin, eyes, and inhalation

  • Use appropriate personal protective equipment (PPE)

  • Handle under dry and well-ventilated conditions

  • Refer to the Safety Data Sheet (SDS/MSDS) before use




Regulatory & Documentation


Available upon request:

  • COA (Certificate of Analysis)

  • SDS / MSDS

  • TDS (Technical Data Sheet)

  • Export and regulatory compliance documents




Why Choose Our 4-Chlorobenzenesulfonyl Chloride?


  • ✔ Stable purity and batch consistency

  • ✔ Suitable for pharmaceutical and agrochemical synthesis

  • ✔ Export-ready packaging and documentation

  • ✔ Flexible MOQ and logistics options

  • ✔ Professional technical support




Frequently Asked Questions (FAQ)


Q1: Is 4-Chlorobenzenesulfonyl Chloride moisture sensitive?


Yes, it reacts with moisture and should be stored and handled under dry conditions.


Q2: What are the main applications of this product?


It is mainly used in pharmaceutical, agrochemical, and fine chemical synthesis.


Q3: Can you provide analytical and regulatory documents?


Yes, COA, SDS, and additional documents are available for each batch.


Q4: What is the typical minimum order quantity (MOQ)?


MOQ depends on packaging and destination; please contact us for specific details.


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