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3-Nitrobenzenesulfonyl Chloride

3-Nitrobenzenesulfonyl chloride its light yellow crystal. Melting point 68.5-69 ℃. Easy to dissolve in ethylene glycol, insoluble in water. Heating causes decomposition.
  • 121-51-7

  • C6H4ClNO4S

  • 221.62

  • 204-476-2

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Product Description

3-Nitrobenzenesulfonyl Chloride


Product Overview


3-Nitrobenzenesulfonyl Chloride is an important aromatic sulfonyl chloride used as a key intermediate in pharmaceutical synthesis, agrochemicals, and fine chemical manufacturing. It is primarily applied in sulfonamide formation and functional group modification reactions due to its highly reactive sulfonyl chloride group.


This compound is widely used in custom synthesis and research-driven industrial applications that require precise reactivity and consistent purity.




Key Product Identification


  • Product Name: 3-Nitrobenzenesulfonyl Chloride

  • Synonyms: m-Nitrobenzenesulfonyl Chloride

  • Chemical Formula: C₆H₄ClNO₄S

  • CAS Number: 98-74-8

  • Molecular Weight: 221.62 g/mol

  • HS Code: 29041000

  • Appearance: Pale yellow to light brown crystalline solid

  • Odor: Pungent, characteristic sulfonyl chloride odor




Chemical & Physical Properties


Property Typical Value
Purity ≥ 98.0%
Physical State Solid
Reactivity Highly reactive with amines and alcohols
Solubility Soluble in common organic solvents
Moisture Sensitivity Moisture-sensitive

Typical values for industrial and export-grade material.




Manufacturing & Quality Control


3-Nitrobenzenesulfonyl Chloride is produced through controlled sulfonation and chlorination reactions under strictly regulated conditions. Each batch undergoes comprehensive quality testing, including:


  • Purity verification (HPLC / GC)

  • Moisture content control

  • Appearance and color inspection

  • Impurity profiling

All shipments are supplied with complete quality documentation.




Applications of 3-Nitrobenzenesulfonyl Chloride


Pharmaceutical Intermediates

Used in the synthesis of sulfonamide-based drug intermediates and active pharmaceutical ingredient (API) precursors.


Agrochemical Synthesis

Applied in the production of herbicide and pesticide intermediates requiring aromatic sulfonyl functionality.


Fine Chemicals & Custom Synthesis

Used in specialty chemical manufacturing, laboratory synthesis, and contract research applications.


Chemical Research

Commonly utilized as a reagent for sulfonylation reactions in organic chemistry research.




Packaging & Logistics


  • Standard Packaging:

    • 25 kg fiber drum

    • 25 kg plastic drum

  • Custom Packaging: Available upon request

  • Storage Conditions:

    • Store in a cool, dry, well-ventilated area

    • Keep tightly sealed and protected from moisture




Safety & Handling


  • Corrosive and moisture-reactive substance

  • Avoid contact with skin, eyes, and inhalation

  • Use appropriate personal protective equipment (PPE)

  • Handle under dry, well-ventilated conditions

  • Refer to the Safety Data Sheet (SDS/MSDS) before use




Regulatory & Documentation


Available upon request:

  • COA (Certificate of Analysis)

  • SDS / MSDS

  • TDS (Technical Data Sheet)

  • Export and regulatory compliance documents




Why Choose Our 3-Nitrobenzenesulfonyl Chloride?


  • ✔ Reliable purity and batch consistency

  • ✔ Suitable for pharmaceutical and fine chemical synthesis

  • ✔ Export-ready packaging and documentation

  • ✔ Flexible MOQ and logistics support

  • ✔ Professional technical service




Frequently Asked Questions (FAQ)


Q1: Is this product suitable for pharmaceutical synthesis?


Yes, it is widely used as a pharmaceutical and API intermediate.


Q2: Is the product moisture sensitive?


Yes, proper dry storage and handling are required to maintain stability.


Q3: Do you provide analytical documentation?


Each batch is supplied with COA and SDS; additional data is available upon request.


Q4: What is the typical minimum order quantity (MOQ)?


MOQ depends on packaging type and destination; please contact us for details.


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