3-Chloropropionyl Chloride

3-Chloropropionyl Chloride CAS No. 625-36-5, also known as β-Chloropropionyl chloride, 3-Chloropropanoyl chloride, or β-Chloropropanoyl chloride, is an organochlorine compound.

This colorless to light yellow or pale brown liquid has a pungent, acrid odor and is moisture-sensitive, reacting violently with water to form 3-chloropropionic acid and HCl.

3-Chloropropionyl Chloride is widely used as a key building block in organic synthesis, pharmaceutical intermediates, and specialty chemical production.

Technical Specifications

Package & Storage

• Net weight 220kg/Barrel, 17.6 MT/20'FCL with pallets

• Keep in original tightly closed container, protected from moisture, direct sunlight, and incompatible materials (water, amines, alcohols). Store in a cool, dry, well-ventilated place.

Benefits of 3-Chloropropionyl Chloride

High Reactivity:

The acid chloride moiety enables efficient acylation of alcohols, amines, and thiols to form esters, amides, and thioesters.

Versatile Intermediate:

The β-chloro group allows for subsequent nucleophilic substitution, cyclization, or elimination reactions.

Broad Compatibility:

Soluble in common organic solvents (e.g., acetone, chloroform, toluene, THF) for easy integration into reaction schemes.

Cost-Effective Synthesis:

Supports streamlined production of complex molecules in pharmaceuticals, agrochemicals, and polymers.

Applications and Uses of 3-Chloropropionyl Chloride

3-Chloropropionyl Chloride serves as a critical building block across multiple industries:

Pharmaceutical Industry

• Key intermediate in the synthesis of active pharmaceutical ingredients (APIs) and drug candidates.

• Used in the preparation of biologically active molecules, including modifiers to enhance drug potency or biocompatibility.

  
  

Agrochemicals

• Employed in the production of herbicides, fungicides, and pesticides.

  
  

Organic Synthesis and Specialty Chemicals

• Precursor for esters, amides, and other functionalized compounds.

• Used in polymer synthesis and functional liquid crystals.

• Building block for adhesives and other specialty materials.

Frequently Asked Questions (FAQs)

Q: What are the main applications of 3-Chloropropionyl Chloride?

A: It serves as a key intermediate in pharmaceutical API synthesis, agrochemicals (herbicides, fungicides), organic synthesis (esters, amides), and specialty polymers/liquid crystals.

Q: Is 3-Chloropropionyl Chloride safe to handle?

A: No, it is highly hazardous: fatal if inhaled, causes severe burns/eye damage, and is corrosive. Strict PPE, ventilation, and training are required.

Q: How should 3-Chloropropionyl Chloride be stored?

A: Store in a cool, dry, well-ventilated area under inert atmosphere in tightly sealed containers to avoid moisture and hydrolysis.

Q: Does 3-Chloropropionyl Chloride react with water?

A: Yes, it reacts violently with water, releasing HCl and forming 3-chloropropionic acid.

Contact Us

For COA, TDS, SDS or related products, please contact us at:

Email: mandy@aozunchem.com

WhatsApp: +86-18452425579

AUTHENTICATION CERTIFICATE