2-Methyltetrahydrofuran (2-MeTHF)

2-Methyltetrahydrofuran, also known as 2-MeTHF, is a cyclic ether with CAS Number is 96-47-9. It is a colorless, volatile liquid has an ether-like odor, partially water-soluble but offers better phase separation in biphasic systems compared to many conventional solvents.

2-Methyltetrahydrofuran (2-MeTHF), a renewable, biomass-derived solvent that serves as an excellent, greener alternative to traditional tetrahydrofuran (THF), dichloromethane (DCM), and hexane.

Technical Specifications

Packaging & Storage

• Net weight 160kgs galvanized steel drum, 12.8MT/20'FCL with pallets.

• Store in an cool, dry, well-ventilated area. Keep away from sources of ignition, oxidizers, acids and alkalis.

Benefits of 2-Methyltetrahydrofuran (2-MeTHF)

Renewable & Green:

Bio-based from hemicellulose-derived furfural, reducing reliance on petroleum-based solvents and lowering carbon footprint.

Superior Stability:

Forms peroxides much more slowly than THF, enhancing safety during storage and use.

Higher Boiling Point:

Allows reactions at elevated temperatures without excessive pressure or solvent loss.

Excellent Solvency:

Effective for organometallic reactions (e.g., Grignard), extractions, and biphasic processes; good replacement for THF, DCM, or hexane.

Improved Phase Separation:

Lower water miscibility at higher temperatures aids efficient workup and recycling.

Lower Toxicity Profile:

ICH Class 3 solvent with reduced environmental and health concerns compared to many traditional options.

Versatile Performance:

Enhances yields in extractions of oils and bioactives while improving oxidative stability of extracted products.

Applications and Uses of 2-Methyltetrahydrofuran (2-MeTHF)

2-MeTHF is a versatile solvent across multiple sectors:

Pharmaceutical and API Manufacturing

• Solvent for Grignard and other organometallic reactions.

• Medium for alkylation, amidation, nucleophilic substitutions, additions, and reductions.

• Extraction solvent in API purification and natural product isolation.

Organic Synthesis and Research

• Replacement for THF in low-temperature lithiations, LAH reductions, and Reformatsky reactions.

• Solvent in metal-catalyzed couplings and peptide synthesis (as a greener alternative to DMF/DCM in some protocols).

Extraction and Industrial Processes

• Green alternative to hexane for lipid and bioactive compound extraction from oilseeds (e.g., higher yields of tocopherols, phenolics, and carotenoids with better oxidative stability).

• Biphasic reactions and extractions where superior phase separation is needed.

• Polymerization and specialty chemical manufacturing.

Other Uses

• Cosmetics (COSMOS-approved for lipophilic extractions).

• Fuel additive research due to high energy density and stability.

• Cleaning and electronics applications as a safer, bio-based option.

Frequently Asked Questions (FAQs)

Q: What is the CAS number for 2-Methyltetrahydrofuran (2-MeTHF)?

A: The CAS Number is 96-47-9.

Q: Is 2-MeTHF a green solvent?

A: Yes.  It is bio-based from renewable agricultural resources, aligns with green chemistry principles, and serves as a sustainable alternative to petroleum-derived solvents like THF and hexane.

Q: How does 2-MeTHF compare to THF?

A: 2-MeTHF offers a higher boiling point, slower peroxide formation, better phase separation with water, and often improved performance in organometallic reactions, while being derived from biomass.

Q: How should 2-MeTHF be stored?

A: Store in tightly sealed containers, in a cool, dry, well-ventilated area away from light, heat, and ignition sources.

Contact Us

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