L(-)-Camphorsulfonic Acid - CAS 35963-20-3

Iyini i-L(-)-Camphorsulfonic Acid?

I-L(-)-Camphorsulfonic acid, eyaziwa nangokuthi (1R)-(-)-10-camphorsulfonic acid noma i-L(-)-CSA, i-optically active organic sulfonic acid enenombolo ye-CAS 35963-20-3.

Uhlaka lwayo lwe-chiral oluqinile olususelwa ku-camphor kanye neqembu le-acidic sulfonic acid eqinile likwenza kube usizo njenge-ejenti yokuxazulula i-chiral, i-pharmaceutical synthesis reagent, i-acid catalyst kanye namakhemikhali akhethekile aphakathi nendawo.

I-L(-)-CSA ibaluleke kakhulu ekuxazululeni ama-amine e-racemic. Ingasabela ngama-enantiomers amabili enhlanganisela eyisisekelo ukwakha usawoti we-diastereomeric onokucwebezela okuhlukile noma ukuziphatha okuncibilikayo. Lo mehluko ungavumela usawoti owodwa ukuthi uhlukaniswe ngokucwebezela okukhethiwe.

I-AOZUN ihlinzeka nge-high-purity L(-)-camphorsulfonic acid yocwaningo, ukuthuthukiswa kwenqubo kanye nokuhlanganiswa kwezimboni. Ukufaneleka kwesicelo esithile semithi noma esilawulwayo kufanele kusungulwe ngokusebenzisa ukufaneleka kwekhasimende.

L(-)-Camphorsulfonic Acid Identification

Inombolo ye-CAS, i-optical rotation ethize kanye nefomu lamakhemikhali kufanele ngaso sonke isikhathi kuhlolwe ndawonye. Amagama omkhiqizo ewodwa angase angathembeki ngoba amanye amakhasi abahlinzeki asebenzisa i-L/D engahambisani, i-R/S kanye namagama azuzisayo/negative.

Kungani Khetha i-AOZUN Njengomhlinzeki Wakho we-L(-)-Camphorsulfonic Acid?

I-AOZUN isekela abathengi abadinga ubunikazi bamakhemikhali obungaguquki, ukuzungeziswa kwe-optical okulawulwayo kanye nemibhalo yokuhlinzeka ngezimboni.

Izinzuzo zethu zokuhlinzeka zifaka:

• High-purity L(-)-CSA for synthesis yezimboni

• Inombolo ye-CAS echaziwe kanye nefomu le-enantiomeric

• Ukuzungezisa okukhethekile okulawulwayo

• Ukubukeka kwekristalu okumhlophe kuya kokumhlophe

• Ukulawula umswakama kanye ne-inorganic-ukungcola

• Isitifiketi Sokuhlaziya esiqondene neqoqo

• I-SDS nokusekelwa kwedokhumenti yobuchwepheshe

• Amanani esampula wokufaneleka kwelabhorethri

• Izinketho zokupakisha zezimboni

• Ukwesekwa kokuthumela kwamanye amazwe

• Usizo lokuhlukanisa amafomu e-L(-), D(+) kanye ne-DL

Lapho ucela ikhotheshini, hlinzeka ngesicelo esihlosiwe, imininingwane edingekayo, inani le-oda, indawo oya kuyo kanye nanoma yimiphi imikhawulo ekhethekile yamanzi, insimbi, i-sulfate noma izincibilikisi eziyinsalela.

Izicaciso ezijwayelekile ze-L(-)-Camphorsulfonic Acid

Ithebula elilandelayo limele ukucaciswa kokuhweba okujwayelekile. Ukucaciswa kokuthengiswa kwe-AOZUN okugunyaziwe kanye Nesitifiketi Sokuhlaziya senqwaba kufanele kubuse okwenziwayo ngakunye.

Ukuzungezisa okuqondile kwe-optical kunengqondo kuphela uma izinga lokushisa lokuhlola, ubude bezansi, i-solvent nokugxilisa ingqondo kuchazwa. Le mibandela kufanele ishiwo ekucacisweni noma ku-COA.

Imiphumela yokuhlola etholwe yi-HPLC, i-acid-base titration noma enye indlela akufanele iphathwe ngokulinganayo ngokuzenzakalelayo. Abathengi kufanele baqinisekise indlela yokuhlaziya lapho beqhathanisa abahlinzeki.

Iyini I-L(-)-Camphorsulfonic Acid Isetshenziselwa?

I-Chiral Resolution yama-Racemic Amines

Uhlelo lokusebenza olwaziwa kakhulu lwe-L(-)-CSA isisombululo se-racemic amines nezinye izinhlanganisela eziyisisekelo.

Uma i-enantiopure acid iphendula ngesisekelo se-racemic, ingakhiqiza osawoti ababili be-diastereomeric. Ngokungafani nama-enantiomers, lawa masawoti angase abe nezakhiwo ezihlukahlukene zomzimba, kuhlanganise:

• Ukuncibilika

• Izinga le-Crystallization

• Ifomu le-Crystal

• Ukuziphatha okuncibilika

• Ukusebenza kokuhlunga

Lo mehluko ngezinye izikhathi ungasetshenziswa ukuhlukanisa usawoti owodwa ngokukhetha. Isisekelo esixazululiwe singase kamuva sikhishwe kusawoti owodwa kusetshenziswa inqubo efanelekile eya ezansi nomfula.

Ukusebenza kokulungiswa kuncike ku-substrate. I-L(-)-CSA ngeke inikeze ukuhlukaniswa okuphumelelayo kwayo yonke i-amine ye-racemic, ngakho ukuhlolwa kwe-solvent ne-crystallization kuyadingeka.

I-Pharmaceutical Intermediates kanye ne-Process Chemistry

I-L(-)-CSA isetshenziswa ezinqubweni zemithi ezikhethiwe njengalokhu:

• I-ejenti yokuxazulula i-chiral

• I-asidi eyenza usawoti

• I-organic synthesis reagent

• Inqubo emaphakathi

• I-reagent yokulawula i-stereochemical

• I-organic acid catalyst eqinile

Ingase isetshenziselwe ukwakha usawoti we-camphorsulfonate, obizwa nangokuthi i-camsilate noma usawoti we-camsylate.

Ukusetshenziswa kwezimboni L(-)-CSA enqubweni yezemithi akwenzi okokusebenza kube i-API, i-excipient noma umkhiqizo wekhemisi. Umthengi kufanele asungule izinga elidingekayo lekhwalithi, izilawuli zokungcola, ukulandeleka kanye nemibhalo yokulawula.

Ukwakhiwa kwe-Camsilate Salts

I-L(-) -I-Camphorsulfonic acid ingasabela ngezinhlanganisela eziyisisekelo ezifanele ukwenza usawoti we-camphorsulfonate.

Ukwakhiwa kukasawoti kungase kushintshe izici ezifana nalezi:

• I-Crystallinity

• I-Hygroscopicity

• Ukuziphatha okushisayo

• Ukuncibilika

• Ukuzinza kwamakhemikhali

• Izici zokuhlunga

• Ukuziphatha kokuphatha

Le miphumela ayikwazi ukubikezelwa kusukela ku-asidi kuphela. Ukuhlolwa kukasawoti, ukwakheka kwezinhlamvu eziqinile kanye nokuhlolwa kokuqina kufanele kuqedwe kunhlanganisela ngayinye eqondiwe.

I-Organic Synthesis kanye ne-Acid Catalysis

Njenge-organic sulfonic acid eqinile, i-L(-)-CSA ingase ihlolwe njenge-acid catalyst noma i-acidic reagent ekuguqulweni kwemvelo okukhethiwe.

Ukusetshenziswa okungenzeka kuhlanganisa:

• I-Acid-catalyzed synthesis

• Izinyathelo zokuvikela nokuvikela

• Ukusabela kokuhlela kabusha

• Ukusabela kwe-condensation

• Ukulungiswa kwama-chiral intermediate

• Ukuhlanganiswa kwe-camphorsulfonate derivatives

Ukuvumelana kokusabela kuncike ku-substrate, i-solvent, izinga lokushisa kanye namanye ama-reagents. Ukuhlolwa kwaselabhorethri kuyadingeka ngaphambi kokukhuphuka.

I-Chiral Reagent ne-Analytical Chemistry

I-L(-)-CSA ingasetshenziswa njengalokhu:

• I-Chiral counterion

• I-reagent ye-derivatization

• I-reagent yokuqaphela i-chiral

• Ingxenye ye-ion-pairing

• Izinto eziyisethenjwa zokuthuthukiswa kwendlela

• I-reagent ocwaningweni lwe-stereochemical

Izinhlelo zokusebenza zokuhlaziya zingadinga imikhawulo eqinile yokuhlola, ukuhlanzeka kokubona, amanzi kanye nokungcola komkhondo kunezinhlelo zokusebenza ezijwayelekile zokuhlanganiswa kwezimboni.

I-Specialty Polymers kanye Nezinto Ezisebenzayo

Ama-Camphorsulfonic acids nawo aphenywa njengama-dopants ane-acidic ekuqhubeni ama-polymers afana ne-polyaniline.

Ifomu le-chiral lingase lisize ukwethula indawo ye-chiral ezintweni ezisebenzayo ezikhethiwe. Lolu wucwaningo olukhethekile kanye nesicelo sezinto zokwakha, futhi ukusebenza kuncike esakhiweni se-polymer, izimo ze-doping kanye nendlela yokucubungula.

I-L(-)-CSA Ixazulula Kanjani I-Racemic Amine?

Ukulungiswa kwe-Chiral ngokwakhiwa kukasawoti ngokuvamile kuhilela izimiso ezine.

1. I-Acid-Base Salt Formation

L(-)-CSA inikela ngeproton ku-amine eyisisekelo. Umphumela we-ammonium camphorsulfonate usawoti we-ionic.

2. Ukwakhiwa kwe-Diastereomeric Salts

Ama-enantiomers amabili e-racemic amine akha amasawoti amabili ahlukene e-diastereomeric ane-enantiomer eyodwa ye-L(-)-CSA.

3. I-Crystallization ekhethiwe

Uma ama-salts amabili ane-solubility ehluke ngokwanele noma ukuziphatha kwe-crystallization, omunye angase acwebezelise ngokukhethayo ohlelweni lwezincibilikisi olukhethiwe.

4. Ukutholwa Kwenhlanganisela Exazululiwe

Usawoti ohlukanisiwe ungelashwa kusetshenziswa inqubo efanele yokukhulula isisekelo samahhala esinothisiwe. Isilinganiso se-enantiomeric, isivuno kanye nokuhlanzeka kwamakhemikhali kufanele kulinganiswe.

Ukulungiswa okuphumelelayo kuncike kokungaphezu kobunikazi be-ejenti exazululayo. Okuguquguqukayo okubalulekile kuhlanganisa:

• Ukwakheka kwe-solvent

• Okuqukethwe kwamanzi

• I-Acid-to-base molar ratio

• Ukugxila

• Ukulandelana kokwengeza

• Iphrofayili yezinga lokushisa

• Izinga lokupholisa

• Ukuxuba

• Ukuhlwanyela

• Isikhathi se-Crystallization

• Izimo zokuwasha

Ukuthuthukisa kufanele kusekelwe ekuhlolweni kokuhlola esikhundleni seresiphi yomhlaba wonke.

L(-), D(+) kanye ne-DL Camphorsulfonic Acid: Uyini Umehluko?

I-L(-)-CSA kanye ne-D(+)-CSA ama-enantiomers. Zinezinto eziningi ezibonakalayo ezingezona i-chiral ezifanayo kodwa zisebenzisana ngokuhlukile nama-chiral substrates.

I-DL-camphorsulfonic acid iqukethe kokubili ama-enantiomers futhi ngokuvamile ayikwazi ukunikeza umsebenzi wokuxazulula ofanayo njengebanga le-enantiopure.

Amafomu ahlukene akufanele ashintshwe ngaphandle kokuhlolwa kwenqubo.

Ingabe L(-) Ihlala Isho Okufanayo Nokuthi (1R)-(-)?

Okokusebenza kwezentengiso okukhonjwe yi-CAS 35963-20-3, L(-)-camphorsulfonic acid ivamise ukuhlonzwa njenge-(1R)-(-)-10-camphorsulfonic acid.

Kodwa-ke, izinhlamvu L kanye no-D azikusunguli ngokuphelele ukumiswa kwe-R/S kuwo wonke amakhemikhali. Izimpawu zokuhlanganisa nokukhipha zibonisa isiqondiso esibhekwa ngokuhlolwa sokuzungezisa amehlo futhi azichazi ngokuzimela ukulungiselelwa okuphelele.

Ukuze uthenge okuthembekile, cacisa:

• Gcwalisa igama lamakhemikhali

• Inombolo ye-CAS

• Ukujikeleza kokubona okudingekayo

• Izimo zokuhlola zokuzungezisa

• Isivivinyo

• Ifomu lamakhemikhali

• Amadokhumenti asekelayo adingekayo

Ingabe i-Optical Rotation iyafana ne-Enantiomeric Purity?

Cha. Ukuzungezisa okukhethekile kuwukuhlonza okubalulekile kobunikazi kanye nokuvumelana, kodwa akuhlali kuyisilinganiso esiphelele sokuhlanzeka kwe-enantiomeric.

Inani elilinganisiwe lingathinteka yilokhu:

• Ukugxila

• I-solvent

• Izinga lokushisa

• Ubude begagasi

• Okuqukethwe kwamanzi

• Ukungcola kwamakhemikhali

• Ukulinganisa insimbi

• Inqubo yokuhlola

Uma ukuhlanzeka kwe-stereochemical kubalulekile, umthengi kufanele acabangele indlela efanelekile yokuhlaziya i-chiral ngaphezu kokuzungezisa okuthile.

Izindlela ezingenzeka zihlanganisa i-chiral HPLC, i-chiral GC noma enye indlela eqinisekisiwe ye-stereochemical elungele okokusebenza.

Ulikhetha Kanjani Ibanga Elilungile L(-)-Camphorsulfonic Acid

Qinisekisa Inombolo ye-CAS kanye ne-Enantiomer

Qinisekisa ukuthi umkhiqizo odingekayo yi-CAS 35963-20-3. Unga-ode kuphela ngamagama e-camphorsulfonic acid noma i-CSA ngoba lawa magama angase futhi abhekisele kumafomu e-D(+) noma e-DL.

Qhathanisa Ukujikeleza Okuqondile Ngaphansi Kwezimo Ezifanayo

Imiphumela emibili yokuzungezisa kufanele iqhathaniswe kuphela uma ukugxilisa ingqondo, i-solvent, izinga lokushisa nobude begagasi kuyafana.

Inani elifana no-−21° ngaphandle kwezimo zokuhlola ezichaziwe aliphelele ekutholeni ukufaneleka komhlinzeki.

Buyekeza Indlela Yokuhlola

Buza ukuthi ukuhlolwa kukalwa ngokuthi:

• I-HPLC

• I-titration yokungathathi hlangothi

• Ukubala kwesisekelo esomile

• Enye indlela eqinisekisiwe

Umphumela we-titration ukala okuqukethwe kwe-asidi kodwa ungase unganikezi ulwazi lokungcola okufanayo nokuhlolwa kwe-chromatographic.

Lawula Amanzi Nokulahlekelwa Ekomisweni

Amanzi angathinta izibalo zokuqukethwe okusebenzayo, i-salt stoichiometry, ukuqedwa kanye nokuziphatha kwecrystallization.

Ukulahlekelwa ekomisweni kanye namanzi e-Karl Fischer kuwukuhlola okuhlukene futhi kungase kuveze imiphumela ehlukene. Qinisekisa ukuthi iyiphi elawula inqubo.

Buyekeza I-Iron, Sulfate kanye Nezinsalela Ze-Inorganic

I-Trace metal nezinsalela ze-inorganic zingathonya:

• Umbala womkhiqizo

• Ukuziphatha kokusabela

• Ukuhlanzwa komfula

• Izinqubo ezizwelayo ku-Catalyst

• Amaphrofayili wokungcola kwezemithi

Amakhasimende anezinqubo ezibucayi kufanele anikeze imikhawulo eqondene nohlelo lokusebenza.

Chaza Izidingo Zokuncibilika Kwezinsalela

Isitatimende esijwayelekile 'njengokuthi 'ukuthobela izinyibilikisi ezisele' asicacisi ngokwanele inqubo elawulwayo.

Umthengi kufanele achaze:

• Yiziphi izincibilikisi okufanele zihlolwe

• Imikhawulo esebenzayo

• Indlela yokuhlaziya

• Ukuthi iqoqo ngalinye lidinga ukuhlolwa

Hlola Ifomu Elingenamanzi noma Elinamanzi

Ifomula ye-molecular C10H16O4S nesisindo se-molecular 232.30 ichaza i-anhydrous L(-)-CSA.

Uma umphakeli ebhala i-C10H18O5S noma isisindo semolekyuli esisondele ku-250.31, umkhiqizo ungase wethulwe njenge-monohydrate noma idatha yomkhiqizo ingase ingahambisani. Qinisekisa ifomu langempela lamakhemikhali, ukucaciswa kwamanzi kanye nesisekelo sokuhlolwa ngaphambi koku-oda.

Inqubo Yokufaneleka Ye-L(-)-CSA Enconyiwe

Isinyathelo 1: Buyekeza Amadokhumenti Abahlinzeki

Qhathanisa ukucaciswa, isampula ye-COA, i-SDS, ulwazi lokukhiqiza nezindlela zokuhlaziya.

Isinyathelo sesi-2: Qinisekisa Ubunikazi Bekhemikhali

Qinisekisa inombolo ye-CAS, ukubukeka, ukuhlolwa kanye nokuhlolwa komazisi okulungile okufana ne-IR noma enye indlela eqinisekisiwe.

Isinyathelo sesi-3: Qinisekisa i-Stereochemical Identity

Linganisa ukuzungezisa okuqondile ngaphansi kwemibandela efanayo eshiwo esimisweni sokuthenga.

Sebenzisa indlela efanelekile ye-chiral lapho ubumsulwa be-enantiomeric kuyisici esibalulekile senqubo.

Isinyathelo sesi-4: Linganisa Ukunyibilika

Hlola okokusebenza ku-solvent yenqubo ehlongozwayo ekugxiliseni okudingekayo kanye nezinga lokushisa.

Irekhodi:

• Isikhathi sokuqedwa

• Ukucaca kwesixazululo

• Umbala

• Indaba engaxazululiwe

• Izinga lokushisa imiphumela

• Imvula ngesikhathi sokupholisa

Isinyathelo sesi-5: Yenza izivivinyo zokuxazulula noma zokwakheka kukasawoti

Ukuze uthole inqubo yokuxazulula i-chiral, hlola ukwakheka kukasawoti kanye nokucwebezela usebenzisa ukuhlola kwezinga elincane.

Kala:

• Isivuno esisodwa

• Ukuhlanzeka kwamakhemikhali

• Isilinganiso se-Enantiomeric

• I-Stoichiometry kasawoti

• Ifomu le-Crystal

• Izinga lokuhlunga

• Ukulahlekelwa kukamama notshwala

• Ukukhiqiza kabusha

Isinyathelo sesi-6: Qhathanisa Amaqoqo Amaningi

Lapho uhlelo lokusebenza lubucayi, fanelekela inqwaba yokukhiqiza engaphezu kweyodwa ngaphambi kokugunyazwa kwezohwebo.

Isinyathelo sesi-7: Gcwalisa Isikali Esilawulwayo

Buyekeza ukukhiqizwa kokushisa, ukuxuba, ukulandelana kokwengeza, icrystallization, ukuhlunga kanye nesiqukathi ngaphambi kokwandisa usayizi weqoqo.

I-Solubility kanye nenqubo yokucatshangelwa

I-L(-) -I-Camphorsulfonic acid iyancibilika emanzini futhi ibuye ihambisane nezincibilikisi ezikhethiwe ze-polar organic.

Ukunyibilika kwangempela kuncike kulokhu:

• Ubunikazi be-solvent

• Okuqukethwe kwamanzi

• Izinga lokushisa

• Ukugxila

• Amanye ama-compounds ancibilikile

• Ukuthi i-asidi yamahhala noma usawoti ukhona

Ngezinqubo zokuxazulula, ukuncibilika okuphezulu akufiseleki ngaso sonke isikhathi. Ukwehlukana okusebenzayo kuvame ukuncika ekutholeni umehluko owusizo wokuncibilika phakathi kukasawoti we-diastereomeric.

Ngakho-ke, ukukhetha kwe-solvent kufanele kucabangele kokubili ukwakheka kukasawoti kanye nokucwebezela okukhethiwe.

Ukupakisha kanye Nempahla

Ukupakisha okujwayelekile kwezimboni kungafaka:

• Izikhwama ezivaliwe ezinamalayini okuvikela

• Izigubhu zefiber ezinamalayini angaphakathi

• 25 kg izigubhu zezimboni, ngaphansi kokuqinisekiswa

• Ukupakishwa okuvunywe yikhasimende kuma-oda afanelekile

Ukupakishwa kokugcina kuncike kusayizi we-oda, indawo oya kuyo, izidingo zokuhamba kanye nokucaciswa kwekhasimende.

Iziqukathi ezisetshenziswe kancane kufanele zivalwe kabusha ngokushesha ukuze kunqandwe ukumuncwa komswakama kanye nokungcola.

Isitoreji Nokuzinza

Gcina i-L(-)-camphorsulfonic acid:

• Emaphaketheni angempela avaliwe

• Endaweni epholile, eyomile futhi enomoya omuhle

• Kude nomswakama kanye nokukhanya kwelanga okuqondile

• Kude nezisekelo ezingahambelani nezinto ezisebenzayo

• Emaphaketheni amelana nokubola noma anomugqa ofanele

• Ngaphansi kwemibandela eshiwo ku-AOZUN SDS yamanje

Gwema ukuchayeka isikhathi eside emoyeni onomswakama. Ungabuyisi okungasetshenziswanga noma okungcolile esitsheni sokuqala.

Impilo yeshelufu kufanele isekelwe kulebula yomkhiqizo, ukucaciswa okugunyaziwe kanye nezimo zokulondoloza esikhundleni sesitatimende esijwayelekile sewebhusayithi.

Ukuphatha Okuphephile

I-L(-) -i-camphorsulfonic acid i-asidi ebolayo futhi ingase ibangele ukusha okukhulu kwesikhumba kanye nokulimala okubi kakhulu kwamehlo.

Izilawuli ezinconyiwe zihlanganisa:

• Amagilavu ​​amelana namakhemikhali

• Izingubo zokuzivikela

• Izibuko zokuphepha

• Ukuvikelwa kobuso lapho ukuchaphazeka noma ukuchayeka uthuli kungenzeka

• Ukungenisa umoya ofanele wendawo

• Izinyathelo zokulawula uthuli

• Izinsiza zokuwasha eziphuthumayo ezifinyelelekayo

• Abasebenzi abaqeqeshwe kahle

Gwema ukuphefumula uthuli futhi uvimbele ukuthintana ngqo nesikhumba namehlo.

Ukuhlukaniswa kwezokuthutha kungase kuncike efomini lomkhiqizo, ukupakishwa, indawo kanye nomphakeli wamanje we-SDS. Hlala usebenzisa i-AOZUN SDS yakamuva kanye nemibhalo yokuthumela lapho uhlela ezokuthutha.

Leli khasi lomkhiqizo alithatheli indawo Yephepha Ledatha Yezokuphepha.

Ikhwalithi kanye Namadokhumenti Okunikezwayo

Amadokhumenti atholakalayo kufanele aqinisekiswe lapho ucela ikhotheshini. Ngokuya nge-oda nendawo okuyiwa kuyo, imibhalo ingafaka:

• Isitifiketi Sokuhlaziya esiqondene neqoqo

• Ishidi Ledatha Yezokuphepha

• Ishidi Ledatha Yezobuchwepheshe

• I-invoyisi yezentengiso

• Uhlu lokupakisha

• Idokhumenti yezwe lendabuko

• Amadokhumenti ezokuthutha

• Isitatimende sokukhiqiza

• Isitatimende se-Residual-solvent

• Isitatimende se-Allergen noma semvelaphi yezilwane lapho sisebenza

• Ulwazi lokulawula luyadingeka emakethe yendawo

Amadokhumenti aqondene nesicelo kufanele kuvunyelwane ngawo ngaphambi kokukhishwa kwe-oda lokuthenga.

Ulwazi Oludingekayo Ukuze Ikhotheshini

Ukuze uthole ikhotheshini enembile, hlinzeka:

• Igama lomkhiqizo kanye nenombolo ye-CAS

• Ukuhlolwa okudingekayo

• Kudingeka ukuzungezisa okuqondile nezimo zokuhlola

• Umkhawulo wamanzi noma ukulahleka lapho omiswe khona

• Imikhawulo yensimbi, i-sulfate noma izinsalela ekushiseni

• Izidingo zokuncibilika kwensalela

• Inani elidingekayo

• Ukusetshenziswa okulinganiselwe konyaka

• Isicelo esihlosiwe

• Imfuneko yokupakisha

• Imbobo okuyiwa kuyo noma ikheli lokulethwa

• I-Incoterm edingekayo

• Ikhwalithi edingekayo namadokhumenti okuthumela

• Imfuneko yesampula

imibuzo ejwayelekile ukubuzwa

Ithini inombolo ye-CAS ye-L(-)-camphorsulfonic acid?

Inombolo ye-CAS ye-L(-)-camphorsulfonic acid, evame ukuhlonzwa njenge-(1R)-(-)-10-camphorsulfonic acid, i-35963-20-3.

Ithini ifomula yayo efanele yamangqamuzana?

I-molecular formula ye-anhydrous L(-)-camphorsulfonic acid yi-C10H16O4S, futhi isisindo sayo samangqamuzana silinganiselwa ku-232.30 g/mol.

Ikuphi ukusetshenziswa okuyinhloko kwe-L(-)-camphorsulfonic acid?

Ukusetshenziswa kwayo kwezimboni okuyinhloko kufana ne-ejenti yokuxazulula i-chiral yama-racemic amine nezinye izinhlanganisela eziyisisekelo. Ibuye isetshenziswe ekwakhiweni kukasawoti, kumakhemikhali wenqubo yezemithi, ekuhlanganiseni kwe-organic kanye nocwaningo lwezinto ezikhethekile.

Iwahlukanisa kanjani ama-enantiomers?

Isabela ngesisekelo somjaho ukwenza usawoti we-diastereomeric amabili. Uma usawoti unokuncibilika okuhlukile noma ukuziphatha kwecrystallization, omunye angase ahlukaniswe ngokukhetha.

Ingabe i-L(-)-CSA iyafana ne-D(+)-CSA?

Cha. Zingama-enantiomers aphambene anezinombolo ze-CAS ezihlukile nokuzungeza kokubona okuphambene. I-L(-)-CSA inenombolo ye-CAS 35963-20-3, kuyilapho i-D(+)-CSA ivamise ukuba nenombolo ye-CAS 3144-16-9.

Ingabe i-DL-camphorsulfonic acid ingangena esikhundleni se-L(-)-CSA?

Hhayi kunqubo ye-chiral-resolution. I-DL-camphorsulfonic acid i-racemic futhi ngokuvamile ayikwazi ukunikeza ukucwaswa okufanayo kwamakhemikhali njenge-ejenti yokuxazulula i-enantiopure.

Yikuphi ukuzungezisa okuthile okufanele i-L(-)-CSA ibe nakho?

Ibanga elivamile lezentengiso licishe libe ngu-−21.0° ukuya ku-−23.0°. I-solvent, i-concentration, izinga lokushisa kanye nobude begagasi kufanele kuchazwe ngaphambi kokuthi imiphumela iqhathaniswe.

Ingabe ukuzungezisa okuthile kufakazela ubumsulwa be-enantiomeric?

Hhayi ngokwalo. Iwusizo ekukhombeni nasekuhambisaneni kwenqwaba, kodwa indlela yokuhlaziya ye-chiral eqinisekisiwe ingase idingeke uma ukuhlanzeka kwe-enantiomeric kubalulekile.

Ingabe i-L(-)-camphorsulfonic acid iyancibilika emanzini?

Yebo. Iyancibilika emanzini. Ukuncibilika enqubweni yangempela kuzoncika ekugxiliseni, izinga lokushisa, ezinye izakhi nokuthi ingabe usawoti wakhekile.

Ingabe i-AOZUN L(-)-CSA iyibanga lezemithi?

I-L(-)-CSA ingase ihlinzekwe ukuze kuhlanganiswe imithi kanye nezicelo zamaphakathi, kodwa igama elithi ibanga lemithi kufanele lisetshenziswe kuphela lapho izinga elichaziwe lekhwalithi, uhlelo lokukhiqiza kanye nemibhalo esekelayo kuvunyelwene ngayo.

Akufanele ichazwe ngokuzenzakalelayo njenge-API noma i-excipient yezemithi.

Yiziphi izinkomba zekhwalithi ezibaluleke kakhulu?

Izinkomba eziyisihluthulelo ziwukuhlola, ukuzungezisa ukubona okuqondile, amanzi noma ukulahleka lapho omiswa, ubunikazi bamakhemikhali, ukubukeka, ukuziphatha okuncibilika kanye nokungcola okuhambisana nokusetshenziswa.

Kufanele ugcinwe kanjani umkhiqizo?

Yigcine ivalwe ngokuqinile endaweni epholile, eyomile futhi enomoya omuhle. Ivikele emswakama, elangeni, ekungcoleni nasezintweni ezingahambelani. Landela umkhiqizo wamanje we-SDS.

Ingabe i-AOZUN inganikeza isampula?

Ukutholakala kwesampula kungaqinisekiswa ngokuya ngebanga, indawo okuyiwa kuyo kanye nenani elidingekayo. Faka isicelo esihlosiwe kanye nokucaciswa lapho ucela isampula.

Cela Isampula L(-)-Camphorsulfonic Acid noma Ikhotheshini

I-AOZUN ihlinzeka nge-L(-)-camphorsulfonic acid, CAS 35963-20-3, ukuze kulungiswe i-chiral, i-pharmaceutical intermediate, i-organic synthesis kanye nezicelo zamakhemikhali ezikhethekile.

Xhumana ne-AOZUN ngemininingwane yakho edingekayo, inani, isicelo, ukupakishwa kanye nendawo oya kuyo ukudiliva. Ithimba lethu lizoqinisekisa izinga elitholakalayo, imibhalo yeqoqo, ukutholakala kwesampula kanye nemibandela yokuthengisa.