N-Methylaniline (NMA) CAS 100-61-8

What Is N-Methylaniline?

N-Methylaniline, commonly abbreviated as NMA, is a secondary aromatic amine used as an intermediate in dyes, pigments, fine chemicals, agrochemical synthesis, pharmaceutical synthesis and selected industrial formulations.

Its chemical formula is C7H9N, and its CAS number is 100-61-8. N-Methylaniline is normally supplied as a clear, colorless to pale-yellow oily liquid. Prolonged exposure to air, light or unsuitable storage conditions may cause the material to become darker.

As an N-methylated derivative of aniline, NMA retains one hydrogen atom on the nitrogen. This structure gives it different reactivity from both aniline and N,N-dimethylaniline.

AOZUN supplies N-Methylaniline for industrial synthesis and international distribution. Batch specifications, packaging, documentation and delivery options can be discussed according to the customer’s application and destination market.

N-Methylaniline Quick Facts

Physical-property values are reference data rather than release specifications. The applicable sales specification and batch certificate of analysis should govern acceptance.

Is N-Methylaniline the Same as Methylaniline?

The name “methylaniline” can be ambiguous because a methyl group can be attached either to the nitrogen atom or to the aromatic ring.

N-Methylaniline has the methyl group attached directly to nitrogen:

C6H5–NH–CH3

It should not be confused with:

• 2-Methylaniline, also known as o-toluidine

• 3-Methylaniline, also known as m-toluidine

• 4-Methylaniline, also known as p-toluidine

• N,N-Dimethylaniline, CAS 121-69-7

N,N-Dimethylaniline contains two methyl groups attached to nitrogen and is a tertiary amine. It is not a synonym for N-Methylaniline.

Buyers should always use CAS 100-61-8 on inquiries, purchase orders, specifications and shipping documents to prevent identification errors.

N-Methylaniline Product Specifications

The following table presents a typical industrial supply profile. Contract specifications may differ by grade and application. Confirm the final requirements in AOZUN’s quotation and batch-specific COA.

Higher purity or tighter impurity control may be available after technical review. Customers should identify the impurity that creates the greatest risk in their downstream process rather than selecting material by total assay alone.

Why Do NMA Impurities Matter?

Aniline Content

Aniline is a common related impurity because it may remain from the manufacturing process.

In downstream synthesis, excess aniline may:

• Form unwanted reaction products

• Change product selectivity

• Complicate purification

• Alter dye shade or performance

• Increase the analytical burden on regulated intermediates

A buyer using NMA in a selective synthesis may therefore require a tighter aniline limit than a buyer using it in a less sensitive industrial process.

N,N-Dimethylaniline Content

N,N-Dimethylaniline may form through further methylation of N-Methylaniline.

Unlike NMA, N,N-dimethylaniline has no nitrogen–hydrogen bond. This changes its reactivity and may make it unsuitable for reactions that depend on the secondary amine structure.

The N,N-dimethylaniline limit should be evaluated separately from total purity.

Water Content

Water can influence:

• Reaction rate

• Catalyst activity

• Phase separation

• Product yield

• Hydrolysis-sensitive intermediates

• Storage stability

Karl Fischer titration is normally more informative than a general loss-on-drying test for low-level water measurement in liquid organic chemicals.

Color and Oxidation

Fresh high-purity N-Methylaniline may be colorless or pale yellow. The material can darken during exposure to air, light or unfavorable storage conditions.

Color change does not provide a complete purity measurement. A darker sample should be evaluated using GC, water, color and other relevant tests rather than accepted or rejected by appearance alone.

How Is N-Methylaniline Used?

N-Methylaniline is primarily used as a reactive building block. Suitability depends on the downstream process, impurity limits and applicable regulations.

Dyes and Pigment Intermediates

NMA can introduce an N-methylphenylamino group into dye and pigment intermediates. Its secondary amine functionality supports reactions used to build more complex colorant structures.

Important purchasing factors include:

• GC purity

• Aniline content

• N,N-dimethylaniline content

• Color

• High-boiling impurities

• Batch consistency

For shade-sensitive production, a trial batch should be tested in the customer’s actual formulation.

Fine Chemical Synthesis

N-Methylaniline is used as an intermediate in reactions such as alkylation, acylation, condensation and other transformations involving aromatic amines.

Process developers should consider its:

• Nucleophilicity

• Basicity

• Secondary amine structure

• Solvent compatibility

• Water content

• Impurity profile

Laboratory conversion data should be verified before commercial scale-up.

Agrochemical Intermediates

NMA may be used to manufacture selected crop-protection intermediates. It is not itself automatically an approved pesticide active ingredient.

For regulated synthesis, buyers may require:

• Enhanced impurity documentation

• Consistent production route

• Batch traceability

• Retained samples

• Change-notification procedures

• Additional regulatory declarations

The suitability of NMA must be assessed against the registration and impurity requirements of the final product.

Pharmaceutical and Specialty Intermediates

N-Methylaniline can be used as a building block in selected pharmaceutical and specialty chemical routes.

Industrial-grade NMA should not be described as pharmaceutical grade unless a defined pharmaceutical specification, quality system and regulatory framework have been established.

Customers should communicate any requirements for elemental impurities, related substances, residual solvents or manufacturing traceability before ordering.

Rubber and Polymer Chemicals

NMA may be used as an intermediate in the synthesis of selected rubber-processing chemicals, stabilizers or other polymer additives.

Performance claims should apply to the final manufactured additive rather than to N-Methylaniline alone.

Fuel and Octane-Related Applications

N-Methylaniline has been used as an octane-enhancing component in certain fuel formulations and markets. However, fuel-additive rules differ significantly by country and product standard.

Use in gasoline is not automatically permitted. Buyers must verify:

• National fuel standards

• Maximum permitted concentration

• Emissions requirements

• Toxicological restrictions

• Registration obligations

• Engine and after-treatment compatibility

• Finished-fuel labeling rules

AOZUN does not recommend fuel use without written confirmation that the intended formulation complies with the destination market’s regulations and specifications.

Why Choose AOZUN as Your N-Methylaniline Supplier?

Application-Based Product Selection

AOZUN can discuss the customer’s end use, required purity, related impurities, packaging and destination before confirming a suitable supply option.

Batch-Specific Quality Documentation

Available documentation can be confirmed during quotation and may include:

• Certificate of analysis

• Safety data sheet

• Technical data sheet

• Product identification information

• Packing details

• Country-of-origin information

• Transport documentation

Industrial Packaging Options

Drum, IBC or other approved industrial packaging may be available depending on the order quantity, transport route and local dangerous-goods requirements.

The final packaging type and net weight must be stated in the sales contract.

International Supply Support

For export orders, AOZUN can coordinate commercial documentation, packaging information and shipping requirements with the buyer and logistics provider.

Import clearance and local regulatory approval remain the buyer’s responsibility unless otherwise agreed in writing.

How Should Buyers Evaluate an N-Methylaniline Supplier?

Do not evaluate a supplier using purity and price alone. Confirm the following points before ordering:

1. Is the product identified by CAS 100-61-8?

2. Which analytical method is used for purity?

3. Are aniline and N,N-dimethylaniline reported separately?

4. Is water measured by Karl Fischer titration?

5. Is color included in the agreed specification?

6. Is a batch-specific COA available?

7. Can the supplier maintain consistent impurity limits?

8. What packaging is used?

9. Is the packaging approved for the intended transport route?

10. Are SDS and transport documents current?

11. What is the manufacturing or dispatch lead time?

12. Can a sample or trial quantity be evaluated first?

For sensitive synthesis, customers should test NMA in their own process before approving a new source.

Quality Control for N-Methylaniline

Gas Chromatography

GC is commonly used to measure N-Methylaniline assay and related organic impurities.

A meaningful specification should clarify whether the reported result is:

• GC area percentage

• Mass percentage

• Assay after correction

• Result calculated on an anhydrous basis

Results generated by different methods may not be directly comparable.

Karl Fischer Water Testing

Karl Fischer titration measures water more specifically than visual inspection or general drying tests. It is particularly relevant when NMA will be used in a moisture-sensitive process.

Color Testing

Color may be evaluated visually or by an agreed instrumental method. The test method, sample cell and color scale should be defined if color is a critical purchasing parameter.

Density and Refractive Index

Density and refractive index can support identity and consistency checks. These measurements do not replace GC analysis because a contaminated sample may still fall within a broad physical-property range.

Retained Samples and Traceability

For long-term supply, both supplier and customer should consider retaining representative samples. Batch numbers should connect the product, COA, packaging and shipment records.

Packaging, Storage and Shelf-Life Guidance

Keep N-Methylaniline in tightly closed, compatible containers in a cool, dry and well-ventilated area.

Recommended controls include:

• Protect the product from air and direct light

• Keep containers securely closed

• Store away from heat and ignition sources

• Separate from strong oxidizing agents

• Avoid uncontrolled contact with strong acids

• Use compatible seals, pumps and transfer lines

• Prevent moisture and cross-contamination

• Maintain secondary containment

• Restrict access to trained personnel

An inert atmosphere may be appropriate where color stability or long storage periods are important. Follow the current AOZUN SDS and the packaging manufacturer’s compatibility guidance.

Shelf life should be based on the supplied grade, packaging, storage conditions and sales documentation—not assumed from general online data.

N-Methylaniline Safety and Handling

N-Methylaniline is an acutely toxic chemical. It may be toxic if swallowed, inhaled or absorbed through the skin. Exposure can affect the blood’s ability to transport oxygen and may cause methemoglobinemia.

Potential warning signs can include:

• Headache

• Dizziness

• Weakness

• Shortness of breath

• Bluish coloration of lips, skin or fingernails

Use closed transfer systems and effective local ventilation wherever possible. Appropriate chemical-resistant gloves, protective clothing and eye or face protection must be selected from the current SDS and site risk assessment.

NMA is also hazardous to aquatic life. Prevent release into soil, drains and surface water.

Anyone who may be exposed should receive product-specific training. Suspected significant exposure requires immediate professional medical evaluation.

Transport and Regulatory Considerations

N-Methylaniline is commonly transported under:

• UN number: UN 2294

• Proper shipping name: N-Methylaniline

• Primary transport class: 6.1

• Packing group: commonly III

Classification, labeling and documentation must be verified against the latest applicable SDS and transport regulations for the shipment route.

Before importing or using NMA, buyers should determine whether they need:

• REACH coverage or an only representative

• TSCA status confirmation

• Local chemical registration

• Workplace exposure controls

• Dangerous-goods import permits

• Environmental reporting

• End-use declarations

• Fuel-additive approval

Regulatory status can change and must be checked for the destination country and intended application.

Information to Include in Your NMA Inquiry

For a faster quotation, provide:

• Product name: N-Methylaniline

• CAS number: 100-61-8

• Required purity

• Maximum aniline content

• Maximum N,N-dimethylaniline content

• Maximum water content

• Color requirement

• Required quantity

• Preferred packaging

• Destination port or delivery address

• Intended application

• Required documents

• Expected delivery schedule

If the specification is still under development, AOZUN can review the intended application and help identify the most important parameters to confirm.

Frequently Asked Questions

What is another name for N-Methylaniline?

Common names include monomethylaniline, N-methylbenzenamine and N-methylaminobenzene.

What is the CAS number of N-Methylaniline?

The CAS number is 100-61-8.

Is N-Methylaniline the same as N,N-Dimethylaniline?

No. N-Methylaniline is a secondary amine containing one N-methyl group and one N–H bond. N,N-Dimethylaniline is a tertiary amine with two methyl groups attached to nitrogen.

Is N-Methylaniline the same as o-toluidine?

No. In N-Methylaniline, the methyl group is attached to nitrogen. In o-toluidine, the methyl group is attached to the aromatic ring.

What does N-Methylaniline look like?

It is normally a clear, colorless to pale-yellow oily liquid. Exposure to air and light can cause darkening.

Is N-Methylaniline soluble in water?

Its solubility in water is limited. Its behavior in a specific formulation should be verified experimentally.

Why does N-Methylaniline become darker during storage?

Oxidation and exposure to air, light or unsuitable storage conditions can produce colored species. Color should be assessed together with GC and other quality tests.

Which impurities should buyers monitor?

Aniline, N,N-dimethylaniline, water, low-boiling substances, high-boiling substances and color are commonly relevant.

Can N-Methylaniline be used as an octane booster?

It has been used in certain fuel formulations, but permission and concentration limits vary by jurisdiction. Buyers must confirm compliance before use.

What documents are available with an order?

COA, SDS, TDS, packing information and transport documentation may be available depending on the product grade and order. Confirm the required documents during quotation.

Can AOZUN provide a sample?

Sample availability depends on destination, quantity, dangerous-goods shipping restrictions and the requested grade. Contact AOZUN with the complete delivery information.

Request an N-Methylaniline Quote

AOZUN supplies N-Methylaniline CAS 100-61-8 for industrial synthesis and international distribution.

Send us your required purity, impurity limits, quantity, packaging and delivery destination. Our team will review product availability, documentation and logistics requirements before providing a quotation.